Anti-inflammatory activity of Mi LABS Joint Support supplement (MLJS-01) in RAW 264.7 cell lines

Authors

  • T. K. Renish Maven iLab Pvt. Ltd., No 1, First Floor, 10th Main 2nd Cross, Nandanam Colony, Horamavu Main Road, Bangalore - 560 043. India

Abstract

The aim of this study was to investigate the effect of Mi LABS Joint Support supplement (MLJS-01) on the production of TNF-α, an important inflammatory mediator, in RAW 264.7 cell lines. Isolated RAW 264.7 cells were activated with 1 µg/ml lipopolysaccharide in the presence of MLJS-01 (25 and 50 µg/ml) and Dexamethasone (200 µM). Tumor necrosis factor-α secretion was quantified after 4h by L-929 bioassay. MLJS-01 showed dose dependent inhibition (31.19±3.40 and 24.75±4.82% at 50 and 25μg/ml, respectively) of LPS-induced TNF-α production in RAW 264.7 cell lines. The reduced production of TNF-α in RAW 264.7 cell lines may be involved in anti-inflammatory activity conveyed by MLJS-01.

Keywords:

Anti-inflammatory, Joint Support, TNF-α, Macrophages, Lipopolysaccharide

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Published

06-07-2015
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How to Cite

Renish, T. K. “Anti-Inflammatory Activity of Mi LABS Joint Support Supplement (MLJS-01) in RAW 264.7 Cell Lines”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 2, no. 3, July 2015, pp. 34-348, https://jipbs.com/index.php/journal/article/view/76.

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Section

Research Article