Design, Development and Evaluation of Herbal Gel for Treatment of Psoriasis

Authors

  • Patil S. C. Shri Bhagwan College of Pharmacy, Cidco, N-6, Aurangabad, India
  • Gadade D. D. Shri Bhagwan College of Pharmacy, Cidco, N-6, Aurangabad, India
  • Rathi P. B. Shri Bhagwan College of Pharmacy, Cidco, N-6, Aurangabad, India

DOI:

https://doi.org/10.56511/JIPBS.2015.v2.i01.pp72-87

Abstract

The aim of present study was to prepare herbal gel formulation containing methanolic extract of Ricinus Communis on psoriasis. Topical gel formulation was designed by using methanolic extract of seeds of Ricinus Communis in varied concentrations. The gel was prepared by using carbopol 940(1%w/v), Ricinus Communis Extract, ethanol, propylene glycol, methyl paraben, propyl paraben, EDTA disodium, tri-ethanolamine and required amount of distilled water. The prepared gels were evaluated for physical appearance, pH, spread ability, drug content, swelling index, diffusion study, viscosity, homogeneity and grittiness. It was inferred from results that gel formulations were good in appearance and homogeneity

Keywords:

Ricinus Communis, carbopol 940, herbal gel, psoriasis

Downloads

Download data is not yet available.

References

Traub, M.; Marshall, K.; Psoria sis - Pathophysiology, Convensional and Alternative Approaches to Treatment. Alternative medicine review 2007,12,319 - 330 .

Kaur, L.P.; Guleri, T.K.; Topical gel: A Recent Approach For Novel Drug delivery. Asian journal of biomedical and Pharmaceutical Scien ces 2013, 3, 1 - 5 .

Thermo Scientific Application Note 325. Extraction of Oils from Oilseeds by Accelerated Solvent Extraction. 2004 .

Mbah, C. C.; Builders. P. F.; Akuodor, G. C; et al. Pharmaceutical Characterization of Aqueous Stem Bark Extract of Bride liaferrugineaBenth,Tropical Journal of Pharmaceutical Research 2012, 4, 637 - 644.

Khandelwal, K. R.; Practical Pharmacognosy, 19th Edition; NiraliPrakashan; Pune, 2008; pp 157 - 161

Baranowska, I.; Srogi, K.; Włochowicz, A. et.al. Determination of Heavy Metal Contents in Samples of Medicinal Herbs. Polish Journal of Environmental Studies 2002, 11, 467-471

Indian Pharmacopoeia. The indian pharmacopeia commission. Ghaziabad, 2010, vol.1, pp 37 - 48

Sibi, G.; Devi, G.; Dhananjaya, K. et al. Anti - Dandruf f Activity of RicinuscommunisL.Leaf Extracts. International journal of current pharmaceutical Reseach 2012, 4, 74 - 76

Singh, I.; Kumar, P. Preformulation Studies For Direct Compression Suitability Of Cefuroxime Axetil And Paracetamol: A Graphical Represe ntation Using Sedem Diagram. ActaPoloniaePharmaceutica ñ Drug Research 2012, 69, 87 - 93.

Sankar, A.; Chandrashekaran, A. K.; Durga, S.; et al. Formulation and stability Evaluation of Diclofenac Sodium Opthalmic Gel. Indian J. Pharm. Sci. 2005, 473 - 476

Pandey, A.; Jagtap, J. V.; Polshettiwar, S. A.; Formulation and evaluation of in-vitro antimicrobial activity of gel containing essential oils and effect of polymer on their antimicrobial activity. Int J Pharm PharmSci 2011, 3, 234 - 237

Pawar, D. P ; Shamkumar, P. B.; Formulation and evaluation of herbal gel containing lantana camaraleaves extract. Asian J Pharm Clin Res. 2012, 6, 122 - 124

Waghmare, N.; Waghmare, P.; Wani, S. et al; Development of Isotretinoin Gel for the Treatment of Acne Vulgari s. Research Journal of Pharmaceutical, Biological and Chemical Sciences 2011, 2, 220 - 230

Jambaninj, D.; Suleman, S.; Gillani, S. W.; Technological study of preparing gel from semi - solid extract of Cacaliahastata L.. J. Adv. Pharm. Tech. Res 2012, 3, 25 - 29

Das, K.; Dang, R.; Machale, M. U.; Formulation and Evaluation of A Novel Herbal Gel Of Stevia Extract. Iranian Journal of Dermatology 2010, 12, 117 - 122.

Goyal, S.; Sharma, P.; Ramchandani, U.; et al Novel Anti - Inflammatory Topical Herbal Gels C ontaining Withaniasomnifera and Boswelliaserrata. International Journal of Pharmaceutical & Biological Archives 2011, 2, 1087 - 1094.

Ramane, S. B; Syed, V. N.; Biyani, R. K.; Evaluation of Wound Healing Activity of Polyherbal Gel – A Novel Herbal Formul ation. International Journal of Research in Pharmaceutical and Biomedical Sciences 2013, 4, 788 - 794

Negi, A.; Sharma, M.; Singh, M.; Formulation and Evaluation of an Herbal Anti - Inflammatory Gel Containing Eupatorium Leaves Extract. Journal of Pharmaco gnosy and Phytochemistry 2012, 1, 112 - 117

Misal, G.; Dixit, G.; Gulkarni, V.; formulation and Evaluation of herbal gel. indian journal of natural product and resources 2012, 3, 501 - 505

Yamini, K.; Onesimus, T.; Preparation And Evaluation Of Herbal Anti - Acne Gel. Int J Pharm Bio Sci.2013, 4, 956 - 960

Kaur, L. P.; Guleri, T. K. Topical gel: A Recent Approach For Novel Drug delivery. Asian journal of biomedical and Pharmaceutical Sciences 2013, 3, 1 - 5

Kumar, L.; Varma, R.; In vitro evaluation of topical gel prepared using natural polymer. International Journal of Drug Delivery2010. 2, 58 - 63

ICH harmonised tripartite guideline.,validation of analytical procedures: Text And Methodology Q2(R1) Current Step 4 version .,Parent Guideline dated 27 O ctober 1994.

Published

05-01-2015
Statistics
423 Views | 435 Downloads

How to Cite

C., P. S., G. D. D., and R. P. B. “Design, Development and Evaluation of Herbal Gel for Treatment of Psoriasis”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 2, no. 1, Jan. 2015, pp. 72-87, doi:10.56511/JIPBS.2015.v2.i01.pp72-87.

Issue

Section

Research Article