Formulation development and evaluation of Ambroxol HCL paper tablet

Abstract

The possibility to compress ordinary paper into tablets was systematically investigated in this study The SmartFilm®-technology is a novel approach to overcome poor solubility. The technique uses commercial paper in which API can be loaded in amorphous state, thus increasing dissolution rate dc/dt and solubility cs when compared to bulk material. Results proved that tablets can be made from paper, independent of the type of paper used. The tablets appear shiny and with a smooth surface. The pharmaceutical quality was acceptable, i.e., all tablets fulfilled the requirements for tablets according to the Pharmacopeia. The average of drug content was found to be 102.21±2, 101.15±5, 102.10±3, 56.1±7 respectively from F1 to F4. Batch F1 to F4 showed drug release 97.8%, 92.04%, 79.72%, 72.72% respectively.