Antidepressant activity of A. hierochuntica L. effervescent granules using forced swimming test
People in modern society suffer from different psychiatric disorders, in particular depression. Recently, there is a global increase in the use of herbal medicines for psychiatric reasons especial depression. Anastatica hierochuntica L. (Kaff-E-Maryam) is a well-known desert zone medicinal plant widely used as traditional drug in Central Asia, Africa, and elsewhere. The study objective is to assess the antidepressant activity of effervescent granules prepared from aqueous extract of A. hierochuntica effervescent granules were evaluated for flow property (i.e angle of repose, bulk density, tapped density and Hausner’s ratio), particle size distribution and effervescence time. The antidepressant like activity of A. hierochuntica aqueous extract and granules was studied in albino mice using forced swimming test (FST). The formulated effervescent granules exhibited excellent flow properties and bulk density. Effervescence time was less than 15 sec. A. hierochuntica aqueous extract and effervescent granular formula at dose level 20 mg/kg exhibited significant decrease in duration of immobility in FST as compared to – ve control group (p < 0.05). The effect of A. hierochuntica was similar to that of imipramine dose 10mg/kg (p < 0.05). No significant difference was observed in antidepressant activity of A. hierochuntica aqueous extract and the granule form (p > 0.05). Effervescent granules showed that it can be used as a novel approach for using A. hierochuntica for treatment of depression.
Keywords:Effervescent granules, Force Swimming Test, Herbal medicines, Anti-depressant
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Copyright (c) 2019 Siham Abdoun, Tahani I. Hassan, Dalia A. Gaber, Amirah El- Sharekh
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