Antinephrolithiasis effect of ethanol extract of Phaleria macrocarpa (Scheff.) boerl in male wistar rat

Authors

  • Aisyah Mentari Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
  • Urip Harahap Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
  • Panal Sitorus Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.56511/JIPBS.2018.v5.i01.pp42-45

Abstract

Objective: The aim of this research was to determine in vitro and in vivo antinephrolithiasis activity. Methods: In vitro nephrolithiasis activity was performed by incubating calcium oxalate and ethanol extract of Phaleria macrocarpa fruit at 37oC for six hours. In vivo test was induced by administration of 0.75% ethylene glycol and 2% ammonium chloride for 10 days and continued to ethanol extract of Phaleria macrocarpa fruit administration for 10 days then determined calcium oxalate concentration. Results: The in vitro results showed that ethanol extract of Phaleria macrocarpa significantly dissolved calcium oxalate. The in vivo result showed that ethanol extract of Phaleria macrocarpa  fruit decrease calcium oxalate concentration of kidney at dose of 200 and 400mg/kg BW were significantly different (P< 0.05) to negative control.  Conclusion: Ethanol extract of Phaleria macrocarpa fruit has antinephrolithiasis activity on in vitro and in vivo

Keywords:

Calcium oxalate, Ethylene glycol, Nephrolithiasis, Flavonoids

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Published

05-01-2018
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How to Cite

Aisyah Mentari, Urip Harahap, and Panal Sitorus. “Antinephrolithiasis Effect of Ethanol Extract of Phaleria Macrocarpa (Scheff.) Boerl in Male Wistar Rat”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 5, no. 1, Jan. 2018, pp. 42-45, doi:10.56511/JIPBS.2018.v5.i01.pp42-45.

Issue

Volume 5, Issue 1, 2018 (Jan-Mar)

Section

Research Article

Copyright (c) 2018 Aisyah Mentari, Urip Harahap, Panal Sitorus

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