Synthesis of reserpine coupled 1,3,4-oxadiazole derivatives and their biological evaluations
DOI:
https://doi.org/10.56511/JIPBS.2017.v4.i04.pp87-96Abstract
Some novel reserpine coupled 1,3,4-oxadiazole derivatives (RAH1-RAH12) were synthesized in good yields and evaluated for their possible antibacterial, anti-inflammatory activities. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. Their antibacterial activities were evaluated by the disc diffusion method while their anti-inflammatory activities were evaluated by the carrageenan-induced rat paw edema test. All the tested compounds showed moderate to good antibacterial activity when compared with chloramphenicol and high to moderate anti-inflammatory activity when compared to indomethacin. The obtained results showed that the most active compounds could be useful as a template for future design, modification and investigation to produce more active analogs.
Keywords:
Reserpine, 1,3,4-Oxadiazole, Anti-inflammatory activity, Antibacterial activityDownloads
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Copyright (c) 2017 Abhilasha Mittal, Amjad Ali M. Iqbal, Mohib Khan, Firoz A. Kalam Khan
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