Cardiovascular diseases risk factors among chronic kidney diseases male patients
DOI:
https://doi.org/10.56511/JIPBS.2017.v4.i01.pp33-38Abstract
Individuals with chronic kidney disease (CKD) are at a very high risk for the development of cardiovascular disease. In order to improve the prognosis of individuals with CKD, it is important to identify modifiable cardiovascular diseases risk factors and treat them. Objectives: In this study we tried to discover the correlation between progression of chronic kidney disease and traditional and nontraditional cardiac risk factors. Methods: This study was conducted on 40 male patients with chronic renal failure from January to Jun 2013 and a group of 20 healthy male individuals as a control group in El-Zahraa hospital in the west of Libya. Results: The results of this study concluded that, there is a correlation between estimated glomerular filtration rate and serum potassium, cholesterol, and uric acid, also this study proved that there a correlation between serum creatinine concentrations and potassium, cholesterol, triglycerides, and uric acid significantly, on the other hand, no correlation between serum urea levels and all of the tested cardiac risk factors.
Keywords:
Cardiac risk factors, Chronic kidney disease, CKD, Lipids, ElectrolytesDownloads
References
Tonelli M, Wiebe N, Culleton B, et al.: Chronic kidney disease and mortality risk: a systematic review. J Am SocNephrol. 2006; 17(7):20342047.
Levey AS, Beto JA, Coronado BE, Eknoyan G, Foley RN, KasiskeBL, Klag MJ, Mailloux LU, Manske CL, Meyer KB, Parfrey PS, Pfeffer MA, Wenger NK, Wilson PW, Wright JT Jr: Controlling the epidemic of cardiovascular disease in chronic renal disease:What do we know? What do we need to learn? Where do we go from here? National Kidney Foundation Task Force on Cardiovascular Disease. Am J Kidney Dis. 1998; 32:853 – 906.
Uhlig K., Levey AS., and Sarnak MJ: Traditional Cardiac Risk Factors in Individuals with Chronic Kidney Disease. Seminars in Dialysis 2003, 16(2): 118 – 127.
Madero M, Sarnak MJ, Menon V: Uric acid and long-term outcomes in CKD. Am J Kidney Dis. 2009; 53(5):796 – 803.
Lai S, Mariotti A, Coppola B, et al.: Uricemia and homocysteinemia: nontraditional risk factors in the early stages of chronic kidney diseasepreliminary data. Eur Rev Med Pharmacol Sci. 2014; 18(7):1010 – 1017.
Lai S, Coppola B, Dimko M, et al.: Vitamin D deficiency, insulin resistance, and ventricular hypertrophy in the early stages of chronic kidney disease. Ren Fail 2014; 36(1):58 – 64.
Lai S., Mira Dimko, Alessandro Galani, Bettina Coppola, Georgie Innico, Nicla Frassetti, Egidio Domenico Mazzei, and Amalia Mariotti: Early markers of cardiovascular risk in chronic kidney disease. Ren Fail 2015; 37(2): 254 – 261.
Yenigun EC., Cenk Aypak, Didem Turgut, Mehmet Zafer Aydin, Fatih Dede: Effect of metabolic acidosis on QT intervals in patients with chronic kidney disease. Int J Artif Organs 2016; 39(6): 272-276.
Eustace JA, Astor B, Muntner PM, Ikizler TA, Coresh J: Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease. Kidney Int. 2004; 65(3):1031-1040.
Yan GX, Lankipalli RS, Burke JF, Musco S, Kowey PR: Ventricular repolarization components on the electrocardiogram: cellular basis and clinical significance. J Am Coll Cardiol. 2003; 42(3):401-409
Cockcroft DW, Gault MH: Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31-41.
Madore, F: Uremia-Related Metabolic Cardiac Risk Factors in Chronic Kidney Disease. Seminars in Dialysis 2003; 16(2):148 – 156.
Gross ML, Meyer HP, Ziebart H et al.: Calcification of coronary intima and media: immunohistochemistry, backscatter imaging, and Xray analysis in renal and non-renal patients. Clin J Am Soc Nephrol 2006; 2: 121 – 134.
Shanahan CM.: Vascular calcification — a matter of damage limitation? Nephrol Dial Transplant 2006; 21: 1166 – 1169
Ishizaka N, Ishizaka Y, Toda EI et al.: Higher uric acid is associated with increased arterial stiffness in Japanese individuals. Atherosclerosis 2007; 192: 131 – 137.
Mazzali M, Kanellis J, Han L et al.: Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol 2002; 282: F991 – F997.
Kamel, M., El-Sharkawy, M., Afifi, E., Ali, M., Ramadan, A.: Impact of Hyperuricemia on Cardiovascular System in ESRD Patients. The Egyptian Journal of Hospital Medicine 2013; 52: 624 – 629.
Johnson RJ, Kang DH, Feig DI: Is there a pathologic role for uric acid in hypertension, and cardiovascular and renal disease? Hypertension 2003; 41:11831190.
Sanchez-lozada LG, Tapia E, AvilaCasado C: Mil hyperuricemia induces glomerular hypertension in normal rats. Renal physiology in Am J Physiol. 2002; 283:1105-1110.
Noubiap JJ, Naidoo J, and Kengne AP: Diabetic nephropathy in Africa: A systematic review. World J Diabetes. 2015; 6(5): 759-773.
Ruster C and Wolf G: The role of chemokines and chemokine receptors in diabetic nephropathy. Front Biosci 2008; 13: 944-955
Iwano M, Plieth D, Danoff TM, Xue C, Okada H, and Neilson EG: Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002; 110: 341-350.
Guyton, A C., and Hall, J E. Textbook of Medical Physiology 12th Ed. Saunders Elsevier, 2011; 361-363.
Published
How to Cite
Issue
Section
Copyright (c) 2017 Azab Elsayed Azab, Ata Sedik Ibrahim Elsayed
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Journal of Innovations in Pharmaceutical and Biological Sciences is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on a work at