Review on determination of cefepime in biological fluids by different analytical methods

Authors

  • Omkulthom M. A. Department of pharmaceutical sciences, faculty of pharmacy, Princess Nourah bint Abdulrahman university, Riyadh, Saudi Arabia

DOI:

https://doi.org/10.56511/JIPBS.2016.v3.i03.pp141-146

Abstract

Cefepime is one of the important fourth generation cephalosporins used in the management of infections because of its potent and broad-spectrum antimicrobial activity. There are many methods for its analysis also alone or in combination with other drugs in serum, cerebrospinal fluid and urine. Some of those methods are Spectrophotometric, HPLC alone or with MS, HPLC with UV, Electrophoresis and Micellar Electrokinetic Chromatography with UV. This article reviews the different analytical methods of cefepime in the biological fluids.

Keywords:

Cefepime, Chromatography, Spectrophotometry, Electrophoresis, Serum, Biological fluids

Downloads

Download data is not yet available.

References

Dabrowska M, Starek M, Krzek J, Papp E and Krol P: A degradation study of cefepime hydrochloride in solutions under various stress conditions by TLCdensitometry. Biomed Chromatogr. 2015; 29(3):388-395.

Al-Attas A, Nasr JJ, El-Enany N and Belal F: A green capillary zone electrophoresis method for the simultaneous determination of piperacillin, tazobactam and cefepime in pharmaceutical formulations and human plasma. Biomed Chromatogr. 2015; 29(12):1811-1818.

Ghafur A: Sensitivity pattern of Gram negative bacteria to the new β - lactam/ β - lactamase inhibitor combination: Cefepime/tazobactam. Journal of Microbiology and Infectious Diseases 2012; 2(1):5-8.

Abdel-Aziz O, Abdel-Ghany MF, Nagi R and Abdel-Fattah L: Application of Savitzky – Golay differentiation filters and Fourier functions to simultaneous determination of cefepime and the co-administered drug, levofloxacin, in spiked human plasma. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2015; 139:449455.

Cazorla-Reyes R, Romero-Gonzalez R, Garrido Frenich A, Rodriguez Maresca MA and Martinez Vidal JL: Simultaneous analysis of antibiotics in biological samples by ultra high performance liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis 2014; 89:203-212.

Colin P, De Bock L, T'Jollyn H, Boussery K and Van Bocxlaer J: Development and validation of a fast and uniform approach to quantify beta-lactam antibiotics in human plasma by solid phase extractionliquid chromatography-electrospraytandem mass spectrometry. Talanta 2013; 103:285-293

Chen Y-n and Zhang Y: Determination of cefepime in serum by solid phase extraction HPLC. Chinese Journal of Hospital Pharmacy 2006; 26(4):420.

Isla A, Arzuaga A, Maynar J, Gascón A, Solinis M, Corral E and Pedraz J: Determination of ceftazidime and cefepime in plasma and dialysate-ultrafiltrate from patients undergoing continuous venovenous hemodiafiltration by HPLC. Journal of pharmaceutical and biomedical analysis 2005; 39(5):996-1005.

Nemutlu E, Kir S, Katlan D and Beksac MS: Simultaneous multiresponse optimization of an HPLC method to separate seven cephalosporins in plasma and amniotic fluid: Application to validation and quantification of cefepime, cefixime and cefoperazone. Talanta 2009; 80(1):117126.

Palacios F, Mochón M, Sánchez J, López M and Pérez A: Validation of an HPLC method for determination of cefepime (a fourthgeneration cephalosporin). Determination in human serum, cerebrospinal fluid, and urine. Pharmacokinetic profiles. Chromatographia 2005; 62(7-8):355-361.

Iqbal MS, Bahari MB, Darwis Y, Venkatesh G, Gillani SW, Khan AH and Sheshala R: A RP-HPLC-UV Method with Solid Phase Extraction for Determination of Cefepime in Total Nutrient Admixtures: Application to Stability Studies. Current Pharmaceutical Analysis. 2012;8(1):68-74.

López K, Bertoluci D, Vicente K, Dell’Aquilla A and Santos S: Simultaneous determination of cefepime, vancomycin and imipenem in human plasma of burn patients by high-performance liquid chromatography. Journal of Chromatography B. 2007; 860(2):241-245.

Verdier MC, Tribut O, Tattevin P, Le Tulzo Y, Michelet C and Bentue-Ferrer D: Simultaneous determination of 12 betalactam antibiotics in human plasma by high-performance liquid chromatography with UV detection: application to therapeutic drug monitoring. Antimicrob Agents Chemother. 2011; 55(10):48734879.

Ohmori T, Suzuki A, Niwa T, Ushikoshi H, Shirai K, Yoshida S, Ogura S and Itoh Y: Simultaneous determination of eight betalactam antibiotics in human serum by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2011; 879(1516):1038-1042.

Yang Y, Wu W, Yeh H and Chen S: Simultaneous determination of cefepime and vancomycin in plasma and cerebrospinal fluid by MEKC with direct sample injection and application for bacterial meningitis. Electrophoresis 2007; 28(11):1788-1797.

Tseng S, Yang Y, Chen Y and Chen S: Determination of cefepime in plasma and cerebrospinal fluid by micellar electrokinetic chromatography with direct sample injection. Electrophoresis 2004; 25(10‐11):1641 -1647.

Kitahashi T and Furuta I: Method development and validation for the direct determination of cefepime in human serum by micellar electrokinetic capillary chromatography. Current Pharmaceutical Analysis 2006; 2(1):17-21.

Andrási M, Gáspár A and Klekner Á: Analysis of cephalosporins in bronchial secretions by capillary electrophoresis after simple pretreatment. Journal of Chromatography B. 2007; 846(1):355-358.

Published

05-07-2016
Statistics
242 Views | 152 Downloads

How to Cite

Omkulthom M. A. “Review on Determination of Cefepime in Biological Fluids by Different Analytical Methods”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 3, no. 3, July 2016, pp. 141-6, doi:10.56511/JIPBS.2016.v3.i03.pp141-146.

Issue

Section

Review Article