Review on determination of cefepime in biological fluids by different analytical methods

Abstract

Cefepime is one of the important fourth generation cephalosporins used in the management of infections because of its potent and broad-spectrum antimicrobial activity. There are many methods for its analysis also alone or in combination with other drugs in serum, cerebrospinal fluid and urine. Some of those methods are Spectrophotometric, HPLC alone or with MS, HPLC with UV, Electrophoresis and Micellar Electrokinetic Chromatography with UV. This article reviews the different analytical methods of cefepime in the biological fluids.