Free radical scavenging activity of methanolic leaf extract of Pimenta dioica on streptozotocin-induced diabetic rats
DOI:
https://doi.org/10.56511/JIPBS.2015.v2.i04.pp396-401Abstract
The present study was designed to investigate the free radical scavenging activity of Pimenta diocia on streptozotocin (STZ)-induced diabetic rats. The methanolic leaf extract of Pimenta diocia at the doses of 75 and 150 mg/ kg of body weight was administered orally once in a day to the diabetic induced group for 45 days. Glibenclamide (0.6 mg/kg of body weight) was used as reference drug. The antioxidant properties were assessed by estimating the liver and kidney catalase (CAT), thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), glutathione peroxidase (Gpx) and reduced glutathione (GSH). Antioxidant levels were significantly restored towards normal levels in P.dioica treated rats when compared with the STZ control. The results of the study indicate that the Pimenta dioica leaf methanolic extract exhibit promising antioxidant activity towards diabetic rats.
Keywords:
Free radical scavenging activity, Pimenta dioica, glibenclamide, catalaseDownloads
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