A review on comparative study between metformin and hesperidin in the management of diabetic complications

Abstract

Diabetes mellitus (DM) is a highly widespread condition that has a significant negative influence on global health. Typically, they give rise to microvascular and macrovascular challenges like neuropathy, gastropathy, cardiac myopathy, retinopathy, nephropathy etc as well as to an array of comorbidities like depression, cognitive decline, Alzheimer's disease etc. Apart from the use of oral hypoglycemic agent in regulating blood glucose levels that has a role in the development of diabetic complication, flavonoids have been a major research attraction in targeting diabetic complications. Hesperidin a plant based flavone glycoside found abundantly in citrus fruits has gained a lot of attention in medical research with its anti-diabetic, antioxidant and hypolipidemic potential being formulated with novel approaches in diabetes research. This review article not only aims at contrasting the roles of hesperidin and metformin with a systematic approach in various diabetic complications along with associated comorbidities but also provides justifying information for carrying out  a study to determine the effectiveness of combinational strategy between the two in fighting of various diabetic complications and to modulate the progression of the disease.