Lemon juice catalysed efficient one-pot synthesis and in silico ADME prediction of 2-(substituted phenyl) phthalazin-1(2H)-ones

Abstract

Recently, lemon juice has received a lot of attention as a highly efficient and selective biocatalyst for organic synthesis. Lemon juice has a lot of potential as a green chemistry catalyst because it is readily available, affordable, biodegradable, and nontoxic. A simple one-pot, synthetic method for the preparation of 2-(substituted phenyl) phthalazin-1(2H)-ones 3(a-j) is described through the reaction of phthalaldehydic acid, substituted phenyl hydrazine and lemon juice as catalyst. The major advantages of the proposed method are its simplicity, short reaction time, easy work-up, inexpensive catalyst, and good yields. ADME properties were predicted in silico and support the potential of 3(a-j) to show favorable drug-like properties.