The effect of Rosa damascena extract activity on angiotensin converting enzyme and renal function in Wistar rats induced high diet of sodium
DOI:
https://doi.org/10.56511/JIPBS.2022.9402Abstract
Background: Hypertension is known as ‘the silent killer’ because it can appear suddenly and cause various complications which eventually results to death. There are several herbal medicines that can use as antihypertension such as Rosa damascene extract. Objective: The purpose of this research was to determine the effect of Rosa damascene extract (RE) to ACE, renal function (urea, creatinine) and renal histopathology. Methods: The subject of research is male Wistar rat with 150-200 gram in weight, divided into five groups, as follow: P0 = control group; P1 = NaCl 8% + RE 500 mg/kgBW; P2 = NaCl 0.35% + RE 500 mg/kgBW; P3 = NaCl 8% and P4 = NaCl 0.35% for 28 days. After 28 days-treatment, rat blood was taken from the heart for analyzing the ACE activity by ELISA method, while uremic, creatinine by spectrophotometer and renal histopatology assessment using hematoxylin eosin stain method. Results: It was found the difference of ACE activity, urea, creatinine serum in Wistar rat which was before administration of sodium diet with p value < 0.05. Rose flower extract (Rosa damascene) has been proved to be able to decrease the activity of ACE, urea, creatinine serum in Wistar rat which was before given Sodium diet with value of p < 0.05. Rose flower extract (Rosa damascene) was able to provide a nephroprotection effect. Conclusion: Rose flower extract (Rosa damascene) had activity against ACE inhibition, as well as protection of renal function in rats induced by a high sodium diet.
Keywords:
Rosa damascene, Extract, ACE, Renal, SodiumDownloads
References
Wolf - Maier K, Cooper RS, Banegas JR, Giampaoli S, Hense HW, Joffres M, Kastarinen M, Poulter N, Primatesta P, Rodríguez - Artalejo F, Stegmayr B. Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. Jama. 2003 ; 289(18):2363 - 9.
Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwi de d ata. The lancet. 2005 ; 365(9455):217 - 23.
Sawicka K, Szczyrek M, Jastrzebska I, Prasal M, Zwolak A, Daniluk J. Hypertension – the silent killer. Journal of Pre - Clinical a nd Clinical Research 2011; 5(2).
Niklas A, Floty ń ska A, Puch - Walczak A, Polakowska M, Top ór - M ą dry R, Polak M, Piotrowski W, Kwa ś niewska M, Nadrowski P, Paj ą k A, Bielecki W. Prevalence, awareness, treatment and control of hypertension in the adult Polish population – Multi - center National Population Health Examination Surveys – WOBASZ studies. Arch ives o f medical science: AMS. 2018 ; 14(5):951.
Kini S, Kamath VG, Kulkarni MM, Kamath A, Shivalli S. Pre - hypertension among young adults (20 – 30 Years) in coastal villages of Udupi District in Southern India: an alarming scenario. PloS one. 2016 ; 11(4):e0154538.
Sidorenkov G, Navis G. Safety of ACE inhibitor therapies in patients with chronic kidney disease. Expert op inion on drug safety. 2014 ; 13(10):1383 - 95.
Di Raimondo D, Tuttolomondo A, Buttà C, Ratli S, Licata G, Pinto A. Effects of ACE - inhibitors and angiotensin receptor blockers on inflammation. Current p harmaceutical design. 2012 ; 18(28):4385 - 413.
Baniasad A, Khajavirad A, Hosseini M, Shafei MN, Aminzadah S, Ghavi M. Effect of hydro - alcoholic extra ct of Rosa damascena on cardiovascular responses in normotensive rat. Avicenna jo urnal of phytomedicine. 2015 ; 5(4):319.
Haze S, Sakai K, Gozu Y. Effects of fragrance inhalation on sympathetic activity in normal adults. Japanese jou rnal of pharmacology. 20 02 ; 90(3):247 - 53.
Cordell GA, Quinn-Beattie ML, Farnsworth NR. The potential of alkaloids in drug discovery. Phytother Res. 2001; 15(3):183-205.
Owoeye TF, Ajani OO, Akinlabu DK, Ayanda OI, Ajani OO. Proximate composition, structural characterization and phytochemical screening of the seed oil of Adenanthera pavonina linn. Rasayan J Chem. 2017; 10(3):807-14.
González-Rodríguez G, Colubi A, Gil MÁ. Fuzzy data treated as functional data: A one-way ANOVA test approach. Computational Statistics & Data Analysis. 2012; 56(4):943-55.
Filippini T, Malavolti M, Whelton PK, Naska A, Orsini N, Vinceti M. Blood Pressure Effects of Sodium Reduction: Dose – Response Meta - Analysis of Experimental S tudies. Circulation. 2021 ; 143(16):1542 - 67.
Kwakern aak AJ, Toering TJ, Navis G. Body mass index and body fat distribution as renal risk factors: a focus on the role of renal haemodynamics. Nephrology Dial ysis Transplantation. 2013 ; 28(suppl_4):iv42 - 9.
Almeida LF, Tofteng SS, Madsen K, Jensen BL. Role of th e renin – angiotensin system in kidney development and programming of adult blood p ressure. Clinical Science. 2020 ; 134(6):641 - 56.
Akram M, Riaz M, Munir N, Akhter N, Zafar S, Jabeen F, Ali Shariati M, Akhtar N, Riaz Z, Altaf SH, Daniyal M. Chemical constitu ents, experimental and clinical pharmacology of Rosa damascena : a literature review. Journal of Pharmacy and Pharmacology. 2020 ; 72(2):161 - 74.
Leitolis A, Crestani S, Linder ÁE, da Silva - Santos JE. High - salt intake reduces apomorphine - induced penile erection and increases neurally mediated contractile responses of the cavernosal smooth muscle in rats. American jour nal of hypertension. 2019 ; 32(12):1206 - 13.
Almeida LF, Tofteng SS, Madsen K, Jensen BL. Role of the renin – angiotensin syste m in kidney development and programming of adult blood pres sure. Clinical Science. 2020 ; 134(6):641 - 56.
Published
How to Cite
Issue
Section
Copyright (c) 2022 Novita Rachmasari, Chrismis Novalinda Ginting, Linda Chiuman
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Journal of Innovations in Pharmaceutical and Biological Sciences is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on a work at