Candida spp., virulence, resistance, susceptibility to antifungals and their infections: A literature review of the last twenty years

Authors

  • C. G. dos Santos do Nascimento Department of Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
  • V. Marcon Giudice Department of Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
  • J. Spier Borges Department of Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul (RS), Brazil
  • P. Abreu Pereira Department of Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul (RS), Brazil
  • E. da Silva Vieira Department of Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul (RS), Brazil
  • L. de P. Recuero da Silva Department of Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul (RS), Brazil
  • G. Silveira Silva Department of Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul (RS), Brazil
  • F. Costa Charles Department of Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul (RS), Brazil
  • S. Krause Ferrão Department of Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul (RS), Brazil
  • L.Noal Calil Department of Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul (RS), Brazil
  • A. Mezzari Department of Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul (RS), Brazil

Abstract

Yeasts of the genus Candida are part of the microbiota of the skin and mucous membranes. However, when there is a change in the normal microbiota or in the host's immune system they can become pathogenic. It causes infections called candidiasis, which can range from superficial lesions and, in more rare cases, can cause widespread infections, such as candidemia. The frequency of invasive mycoses caused by Candida spp. has been increasing significantly, becoming an important nosocomial fungal pathogeny. In this view, this study aims to review the literature of the last 20 years about vulvovaginal candidiasis, oropharyngeal candidiasis and candidemia, as well as aspects related to its virulence, susceptibility and antifungal resistance. Therefore, research was carried out in the databases: Pubmed, Scielo and Web of Science. For the research, the following keywords were used: “candidiasis” and “resistance” and “susceptibility” and “prevalence” and “virulence” “antifungal” and “age”. The present review updates health professionals in relation to vulvovaginal, oropharyngeal candidiasis and candidemia, focusing on the virulence of pathogens and susceptibility to antifungals. Updating and knowledge related to these infections are extremely important to help health professionals regarding the therapeutic conduct in the face of infections caused by Candida spp.

Keywords:

Candida, resistance, susceptibility

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Published

01-07-2021
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How to Cite

Nascimento, C. G. dos S. do, V. Marcon Giudice, J. Spier Borges, P. Abreu Pereira, E. da Silva Vieira, L. de P. Recuero da Silva, G. Silveira Silva, F. Costa Charles, S. Krause Ferrão, L.Noal Calil, and A. Mezzari. “Candida spp., Virulence, Resistance, Susceptibility to Antifungals and Their Infections: A Literature Review of the Last Twenty Years”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 8, no. 3, July 2021, pp. 31-41, https://jipbs.com/index.php/journal/article/view/411.

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Review Article