Angelica archangelica extract ameliorates the oxidative stress induced by Pseudomonas aeruginosa in rats

Abstract

This study investigated the influence of Angelica archangelica roots aqueous extract on Pseudomonas aeruginosa bacteria. The antimicrobial activity of different concentrations of Angelica was assessed in vitro on two strains of yeast and two strains of fungi. P. aeruginosa antibiotics resistance was confirmed against three antibiotics. Results demonstrated that Angelica had very high activity on the growth of P. aeruginosa. To confirm this activity in vivo, four groups of male wistar albino rats were used. Control group received water only, infection group subjected to bacterial infection for two weeks, treatment group subjected to bacterial infection for two weeks followed by oral administration of Angelica archangelica roots extract for two other weeks and protection group subjected to bacterial infection with oral administration of Angelica archangelica extract for two weeks. At the end of experiment, histopathological examination of kidney and liver specimens was carried out; also blood samples were collected to measure biochemical and oxidative stress parameters. Amelioration of the histological images of both the liver and kidney were observed in both group 3 &4. Biochemical results showed significant enhancement in all parameters measured in group 3 & 4 as compared to group 2. Results were more abundant in group 4 than group 3.  In conclusion, Angelica archangelica roots aqueous extract has the potential to remove the oxidative stress caused by P. aeruginosa which resulted in enhancement of histopathological and biochemical results.