Antidiabetes activity of pirdot leaf water infusion extract (Saurauia vulcani Korth.) in type II diabetes rats induced by nicotinamide-streptozotosin

Authors

  • Elisa Monika Simanjuntak Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia
  • Urip Harahap Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia
  • Panal Sitorus Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia
  • Denny Satria Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia

Abstract

Objective: This study was conducted to determine the effect of pirdot leaf water infusion extract (Saurauia vulcani Korth.) to decrease blood glucose levels in type 2 diabetic rats induced by nicotinamide-streptozotosin. Methods:  Pirdot leaf water infusion extract (Saurauia vulcani Korth) was obtained by infusion method. Animals in this study were type 2 diabetic rats that induced by nicotinamide 110 mg / kg BB and streptozotosin 65 mg / kg BW intraperitoneally. The antidiabetic activity test using pirdot leaf water extract was obtained in 3 different doses, namely 0.25 ml, 0.5 ml, and 1 ml were given orally once a day and observed for 28 days. Results: Pirdot leaf water infusion extract at dose of 0.25 ml, 0.5 ml, and 1 ml for 28 days had an antidiabetic effect in type II diabetic rats induced with nicotinamide-streptozotosin. The antidiabetic activity of pirdot leaf water doses of 0.5 mL, and 1 mL significantly different (p <0.05) to negative controls and extracts of pirdot leaf water at a dose of 0.25 mL but it was not significantly different (p> 0.05) to glibenclamide in influencing the difference (Δ) of rat blood glucose levels. Conclusion: Pirdot leaf water infusion extract could reduce blood glucose levels in type 2 diabetic rats induced by nicotinamide-streptozotosin

Keywords:

Antidiabetic, Saurauia vulcani Korth, Water Infusion extract

Downloads

Download data is not yet available.

Published

05-10-2019
Statistics
46 Views | 33 Downloads

How to Cite

Simanjuntak, E. M., Urip Harahap, Panal Sitorus, and Denny Satria. “Antidiabetes Activity of Pirdot Leaf Water Infusion Extract (Saurauia Vulcani Korth.) in Type II Diabetes Rats Induced by Nicotinamide-Streptozotosin”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 6, no. 4, Oct. 2019, pp. 07-10, https://jipbs.com/index.php/journal/article/view/374.

Issue

Section

Research Article