Antidiabetes activity of pirdot leaf water infusion extract (Saurauia vulcani Korth.) in type II diabetes rats induced by nicotinamide-streptozotosin

Abstract

Objective: This study was conducted to determine the effect of pirdot leaf water infusion extract (Saurauia vulcani Korth.) to decrease blood glucose levels in type 2 diabetic rats induced by nicotinamide-streptozotosin. Methods:  Pirdot leaf water infusion extract (Saurauia vulcani Korth) was obtained by infusion method. Animals in this study were type 2 diabetic rats that induced by nicotinamide 110 mg / kg BB and streptozotosin 65 mg / kg BW intraperitoneally. The antidiabetic activity test using pirdot leaf water extract was obtained in 3 different doses, namely 0.25 ml, 0.5 ml, and 1 ml were given orally once a day and observed for 28 days. Results: Pirdot leaf water infusion extract at dose of 0.25 ml, 0.5 ml, and 1 ml for 28 days had an antidiabetic effect in type II diabetic rats induced with nicotinamide-streptozotosin. The antidiabetic activity of pirdot leaf water doses of 0.5 mL, and 1 mL significantly different (p <0.05) to negative controls and extracts of pirdot leaf water at a dose of 0.25 mL but it was not significantly different (p> 0.05) to glibenclamide in influencing the difference (Δ) of rat blood glucose levels. Conclusion: Pirdot leaf water infusion extract could reduce blood glucose levels in type 2 diabetic rats induced by nicotinamide-streptozotosin