Wound healing activity of ointment Artocarpus lakoocha Roxb. ethanol leaves extract evaluation on excision wound

Authors

  • Cut Riska Andriani Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia
  • Rosidah Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia
  • Aminah Dalimunthe Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia
  • Denny Satria Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia

Abstract

Objectives: To investigate wound healing activity of ointment Artocarpus lakoocha Roxb ethanol leaves extract. Material and methods: The leaves of Artocarpus lakoocha Roxb. were dried and extracted with ethanol, followed by evaporation and freeze-drying. Phytochemicals screening was conducted to determining secondary metabolite. The male rats used were 24 for 6 treatments (betadine as a positive control, base ointment as negative control, ointment of 1%; 3%; 5%; 7%) of Artocarpus lakoocha Roxb leaf extract with each group of 4 male rats. Results: Phytochemicals screening were showed flavonoids, glycoside, saponin, tannin and steroids. The results of the ointment wound healing activity test, a good concentration in healing wounds is a 5% ointment with a percent reduction in wounds on day 3 of 28.43%; the 6th is 45.31%; the 9th is 60.31%; the 12th is 75.62% and the 15th is 88.75%. Conclusion: Finding of the present study provides a baseline data for excision wound healing and potential of Artocarpus lakoocha Roxb. leaves and support their traditional claim

Keywords:

Exicion wound, Artocarpus lakoocha, ointment treatment

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Published

05-01-2019
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How to Cite

Cut Riska Andriani, Rosidah, Aminah Dalimunthe, and Denny Satria. “Wound Healing Activity of Ointment Artocarpus Lakoocha Roxb. Ethanol Leaves Extract Evaluation on Excision Wound”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 6, no. 1, Jan. 2019, pp. 12-14, https://jipbs.com/index.php/journal/article/view/353.

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Research Article