Wound healing activity of ointment Artocarpus lakoocha Roxb. ethanol leaves extract evaluation on excision wound

Abstract

Objectives: To investigate wound healing activity of ointment Artocarpus lakoocha Roxb ethanol leaves extract. Material and methods: The leaves of Artocarpus lakoocha Roxb. were dried and extracted with ethanol, followed by evaporation and freeze-drying. Phytochemicals screening was conducted to determining secondary metabolite. The male rats used were 24 for 6 treatments (betadine as a positive control, base ointment as negative control, ointment of 1%; 3%; 5%; 7%) of Artocarpus lakoocha Roxb leaf extract with each group of 4 male rats. Results: Phytochemicals screening were showed flavonoids, glycoside, saponin, tannin and steroids. The results of the ointment wound healing activity test, a good concentration in healing wounds is a 5% ointment with a percent reduction in wounds on day 3 of 28.43%; the 6th is 45.31%; the 9th is 60.31%; the 12th is 75.62% and the 15th is 88.75%. Conclusion: Finding of the present study provides a baseline data for excision wound healing and potential of Artocarpus lakoocha Roxb. leaves and support their traditional claim