An alkaloid derivative from Coscinium fenestratum exhibit dual COX/LOX inhibition

Authors

  • Shahid Adangam Purath School of Chemical Sciences, Swami Anandatheertha Campus, Kannur University, Kannur, Kerala, India, 670327
  • Sudheesh Sudhakaran School of Chemical Sciences, Swami Anandatheertha Campus, Kannur University, Kannur, Kerala, India, 670327
  • Karickal R Haridas School of Chemical Sciences, Swami Anandatheertha Campus, Kannur University, Kannur, Kerala, India, 670327.

Abstract

Agents that inhibit both Cyclooxygenase (COX) and Lipoxygenase (LOX) are highly recommended in the development of anti-inflammatory drugs. An alkaloid derivative from Coscinium fenestratum was isolated and characterized by UV Visible, IR, 1H NMR, 13C NMR and LC-MS spectroscopy. Dual COX/LOX inhibitory study was performed by high throughput screening assay. In the control (maximum enzyme activity) experiment COX activity of 73 µmol/min was noted, which is reduced to 50 µmol/min by the compound isolated. The standard inhibitors show 38 and 29 µmol/min respectively for Aspirin and Nimesulide. Compound isolated from Coscinium fenestratum also possess significant LOX inhibition when compared to standard inhibitor vanillin.

Keywords:

Coscinium fenestratum, Cyclooxygenase, Lipoxygenase, Aspirin, Nimesulide

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Published

05-01-2018
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How to Cite

Shahid Adangam Purath, Sudheesh Sudhakaran, and Karickal R Haridas. “An Alkaloid Derivative from Coscinium Fenestratum Exhibit Dual COX/LOX Inhibition”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 5, no. 1, Jan. 2018, pp. 117-21, https://jipbs.com/index.php/journal/article/view/300.

Issue

Volume 5, Issue 1, 2018 (Jan-Mar)

Section

Research Article

Copyright (c) 2018 Shahid Adangam Purath, Sudheesh Sudhakaran, Karickal R Haridas

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