In vitro hemostatic activity of ethanol extracts of Beetroot (Beta vulgaris L.) in blood male albino rat

Authors

  • Sony Eka Nugraha Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
  • Edy Suwarso Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
  • Yuandani Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia

Abstract

Objective: The purpose of this research was to determine the in vitro hemostatic activity of   ethanol extract of beetroot (Beta vulgaris L). Methods: In vitro hemostatic activity was performed on whole blood of rat by Lee-White method to determine the clotting time  and the Eustrek method to observe the microscopic picture of clotted blood. Results: The results of  in vitro study showed  that  ethanol extract of Beetroot  at the concentration of 1% and 2% decreased the clotting time at the minute of  24.4+1.14 and 15.9 + 0.65, respectively, as compared to EDTA treatment which did not clot for 120 min (p<0.05) and  microscopically showed that  blood cells appear to be attached to each other at the concentration of 1% and 2% of ethanol extract of Beetroot. The hemostatic activity  of ethanol extract of beetroot showed a dose-dependent  manner in the in vitro study. Conclusion: Ethanol extract of beetroot (Beta vulgaris L) has hemostatic activity on in vitro method.

Keywords:

Beetroot (Beta vulgaris L.), Hemostatic, Lee-white, Eustrek

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Published

05-01-2018
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How to Cite

Sony Eka Nugraha, Edy Suwarso, and Yuandani. “In Vitro Hemostatic Activity of Ethanol Extracts of Beetroot (Beta Vulgaris L.) in Blood Male Albino Rat”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 5, no. 1, Jan. 2018, pp. 34-36, https://jipbs.com/index.php/journal/article/view/285.

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Research Article