Antidiabetic potentiality of aqueous leaf extract of Leucas zeylanica in alloxan-induced diabetic rats

Authors

  • Mycal Dutta Assistant Professor, Department of Pharmacy, BGC Trust University Bangladesh, BGC Biddyanagar, Chandanaish, Chittagong, Bangladesh
  • Md. Waseque Mia Lecturer, Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh
  • Md. Zia Uddin Assistant Professor, Department of Pharmacy, BGC Trust University Bangladesh, BGC Biddyanagar, Chandanaish, Chittagong, Bangladesh
  • Sumaya Sultana Research Fellow, Department of Pharmacy, BGC Trust University Bangladesh, BGC Biddyanagar, Chandanaish, Chittagong, Bangladesh
  • Nabila Tazneen Research Fellow, Department of Pharmacy, BGC Trust University Bangladesh, BGC Biddyanagar, Chandanaish, Chittagong, Bangladesh
  • Sushmoy Barua Research Fellow, Department of Pharmacy, BGC Trust University Bangladesh, BGC Biddyanagar, Chandanaish, Chittagong, Bangladesh

Abstract

The study was designed to evaluate the blood glucose lowering effect of the aqueous extract of Leucas zeylanica leaf using the alloxan-induced diabetic rats and compared the activity with diabetic control and antidiabetic drug (Glibenclamide). Leaf extract (50 mg/kg) of Leucas zeylanica and Glibenclamide were administered to normal and experimental diabetic rats for the duration of 10 days. In the alloxan-induced diabetic rat model, Leucas zeylanica extract (50 mg/kg) significantly (P < 0.05) lowered the fasting blood glucose level. Serum insulin levels were not stimulated in the animals treated with the extract. In addition, changes in body weight and liver glycogen levels assessed in the extract treated to the diabetic rats were compared with diabetic control and normal rats. Significant results (P < 0.05) were observed in the estimated parameters. Surprisingly, body weight was increased significantly (P < 0.05) in Leucas zeylanica treated diabetic group.

Keywords:

Blood glucose lowering effect, alloxan-induced diabetic rats, Glibenclamide, Leucas zeylanica

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Published

05-10-2016
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How to Cite

Mycal Dutta, Md. Waseque Mia, Md. Zia Uddin, Sumaya Sultana, Nabila Tazneen, and Sushmoy Barua. “Antidiabetic Potentiality of Aqueous Leaf Extract of Leucas Zeylanica in Alloxan-Induced Diabetic Rats”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 3, no. 4, Oct. 2016, pp. 121-4, https://jipbs.com/index.php/journal/article/view/198.

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Research Article