Antidermatophytes from bioactive secondary metabolites of local Streptomyces spp.

Abstract

Dermatophytes were considered as pathogenic fungi that invade human skin, nails and hairs and cause dermatomycosis. One hundred and eleven were isolated from both marine and terrestrial Egyptian habitats were screened for their ability to produce bioactive secondary metabolites with antidermatophytic this has been done by cultivating them on ISP2 liquid media for 10 days. The antdermatophytic activity was tested for the produced extracts by well-diffusion methods. Extracts from isolates A1, A3, A10, G5 and P4 exhibited potent antidermatophytic activity against trichophyton mentagrophytes (RCMB 09285), Microsporumcanis (RCMB 07321) and Microsporumgypseum (RCMB 07336).  These potent isolates were identified by studying their morphological, physiological and biochemical characteristics and microscopical studies.