Nephroprotection against streptozotocin diabetes is more effective in combined than single leaves extracts of Gongronema Latifolium and Ocimum Gratissimum L.
This study investigated the nephroprotective potency of combined leaves extracts of Gongronema latifolium (GL) and Ocimum gratissimum L. (OG) against streptozotocin-induced diabetic rats. Thirty-six male albino rats were divided into 6 groups of 6 rats each. Groups A and F received placebo treatment and each served as diabetic and normal controls, B, C and D respectively received 200mg/kg b.w GL and OG and 100mg/kg b.w. each of combined GLOG and E received 5 IU/kg b.w insulin (subcutaneously). After 28 days of treatment, animals were sacrificed and serum collected for analysis of glucose and kidney function indices. From the results, serum concentrations of sodium, chloride, bicarbonate and phosphorus were significantly (p<0.05) reduced while potassium level increased significantly in DC compared to NC and treatment groups. The altered concentrations of these electrolytes observed in single extract treatments were effectively modulated in combined. Also, the extracts significantly (p<0.05) reduced STZ –induced elevation in serum concentrations of glucose, creatinine, urea BUN and uric acid in DC compared to NC. Conclusively, the kidney lesions salvaging effect and the amelioration of diabetes associated perturbations of kidney function indices were more effective in combined than single extracts, hence revealing a positive synergistic interactions of the two extracts.