Ultra Sound Assisted: One Step Cyclocondensation of Biginelli Compounds

Authors

  • Rakesh Sadashiv Dhawanpalli Nowrosjee Wadia College, Pune, India
  • Harish B Kale Nowrosjee Wadia College, Pune, India
  • Pathan Azhar Khan Trainer, Department of Clinical Research, CRB Tech, Pune, India

Abstract

Simple and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3, 4-dihydropyrimidin-2(1H) - one derivatives. This synthesis was performed in the presence of polymer nanocomposite Polyindole-Fe as catalyst. These reactions were performed under solvent free conditions cyclocondensation with ultrasound irradiation as the energy source. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yields (82–92%). The advantages of this novel protocol include the excellent yield, operational simplicity, short time, and the avoidance of the use of organic solvents and friendly preparation. Products were identified using physical and spectroscopic data

Keywords:

3, 4-dihydropyrimidin-2(1H) - one derivatives, Polyindole-Fe, Biginelli reaction

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Published

05-04-2015
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How to Cite

Dhawanpalli, R. S., H. B. Kale, and P. A. Khan. “Ultra Sound Assisted: One Step Cyclocondensation of Biginelli Compounds”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 2, no. 2, Apr. 2015, pp. 209-17, https://jipbs.com/index.php/journal/article/view/60.

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Section

Research Article