Degradation Study of Quinapril by UV Spectroscopy

Abstract

Quinapril hydrochloride is an angiotensin converting enzyme (ACE) inhibitor. It is used to treat hypertension and cardiac failure. The forced degradation studies on drug substance involves photo Acid/base Stress testing, photo degradation, Temperature and or with humidity, Time, pH variation (high and low). In our present research work we have studied the degradation parameters on Quinapril hydrochloride. For this purpose we performed stress testing on the brand of the drug i.e. accupril. According to USP, Quinapril Hydrochloride contains not less than (NLT) 98.5 % and not more than (NMT) 101.5% of (C₂₅H₃₀N₂O₅.HCl), calculated on anhydrous basis. The result of this study concludes that when chosen brand of Quinapril (Accupril) was introduced in 0.1 N NaOH (basic medium) and 0.1 N HCl (acidic medium) the brand showed no degradation Whereas when the chosen brand was exposed to Ultraviolet light (320 nm) for 30 min, heat and water, Accupril showed no degradation.