SARS-COV-2 and female reproductive system
DOI:
https://doi.org/10.56511/JIPBS.2022.9301Abstract
Virus SARS-CoV-2, which causes COVID-19 infection, is transmitted mainly by respiratory droplets and its clinical manifestations vary according to the severity of the disease. The respiratory system is the most affected, but other possible forms of transmission are hypothesized. SARS-CoV-2 enters the cell through the binding of the spike protein of the virus with the ACE2 receptor (angiotensin-converting enzyme 2), but it can also be mediated by proteases or cathepsins. The aim of this study is to evaluate the relationship between the COVID-19 virus and the female reproductive system, and to investigate the possibility of transmission of SARS-CoV-2 through the vaginal fluid. A literature review was carried out in the PubMed, Scielo and Web of Science databases, using the terms: “covid and female genitourinary tract”, “covid and cervical sample”, “covid and HPV”, “covid and intraepithelial lesions”, “covid and female genital tract”. Despite the few reports on the subject, some of them point to the presence of SARS-COV-2 in samples of vaginal fluid, identified by the PCR technique. Additional studies are needed in order to establish a relationship between the findings in the vaginal fluid and the correlation with infection and viral load.
Keywords:
COVID-19, Female reproductive system, ACE 2Downloads
References
Vavoulidis E, Margioula - Siarkou C, Petousis S, Dinas K. SARS ‐ CoV ‐ 2 infection and impact on female genital tract: An untested hypothesis. Med Hypotheses. 2020; 144:110162.
Liu K, Chen X, Ren X, Wu Y, Ren S, Qin C. SARS - CoV - 2 effects in the genit ourinary system and prospects of sex hormone therapy. Asian J Urol. 2021; 8(3):303 - 314.
Goad J, Rudolph J, Rajkovic A. Female reproductive tract has low concentration of SARS - CoV2 receptors. PloS One. 2020; 15(12):e0243959.
Huang HH, Wang PH, Yang YP, Cho u SJ, Chu PW, Wu GJ, Chang CC. A review of severe acute respiratory syndrome coronavirus 2 infection in the reproductive system. J Chin Med Assoc. 2020; 83(10):895 - 897.
Jing Y, Run - Qian L, Hao - Ran W, Hao - Ran C, Ya - Bin L, Yang G, Fei C. Potential influence of COVID - 19/ACE2 on the female repro ductive system. Mol Hum Reprod. 2020; 26(6):367 - 373.
Lee WY, Mok A, Chung JPW. Potential effects of COVID - 19 on reproductive systems and fertility; assisted reproductive technology guidelines and considerations: a review . Hong Kong Med J. 2021; 27(2):118 - 126.
Reis FM, Bouissou DR, Pereira VM, Camargos AF, Dos Reis AM, Santos RA. Angiotensin - (1 - 7), its receptor Mas, and the angiotensin - converting enzyme type 2 are expressed in the human ovary. Fertil Steril. 2011 Jan;95(1) :176 - 81.
Abhari S, Kawwass JF. Endometrial susceptibility to SARS CoV - 2: explained by gene expression across the menstrual cycle? Fertil Steril. 2020; 114(2):255 - 256.
Cui P, Chen Z, Wang T, Dai J, Zhang J, Ding T, Jiang J, Liu J, Zhang C, Shan W, Wang S, Rong Y, Chang J, Miao X, Ma X, Wang S. Severe acute respiratory syndrome coronavirus 2 detection in the female lower genital tract. Am J Obstet Gynecol. 2020; 223(1):13 1 - 134.
Qiu L, Liu X, Xiao M, Xie J, Cao W, Liu Z, Morse A, Xie Y, Li T, Zhu L. SARS - CoV - 2 Is Not Detectable in the Vaginal Fluid of Women With Severe COVID - 19 Infection. Clin Infect Dis. 2020; 71(15):813 - 817.
A Schwartz , Y Yogev , A Zilberman , S Alpern , A Many , R Yousovich , R Gamzu . Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vaginal swabs of women with acute SARS-CoV-2 infection: a prospective study. BJOG. 2021; 128(1):97-100.
Ondic O, Cerná K, Kinkorová - Lunacková I, Nemcová J, Mejchar B, Chytra J, Bouda J. SARS - CoV - 2 RNA may rarely be present in a uterine cervix LBC sample at the asy mptomatic early stage of COVID 19 disease. Cytopathology. 2021; 32 (6):766 - 770.
Rubin ES, Sansone SA, Hirshberg A, Clement EG, Srinivas SK. Detection of COVID - 19 in a Vulvar Lesion. Am J Perinatol. 2020; 37(11):1183 - 1184.
Aslan MM, Yuvac HU, Kose O, Toptan H, Akdemir N, Kor oglu M, Cevrioglu AS, Ozden S. SARS - CoV - 2 is not present in the vaginal fluid of pregnant women with COVID -
J Matern Fetal Neonatal Med. 2020; 1 - 3.
Yuvac HU, Aslan MM, Kose O, Akdemir N, Toptan H, Cevrio glu AS, Atlindis M, Koroglu M. Evaluation of the presence of SARS - COV - 2 in the vaginal fluid of reproductive - aged women. Ginekol Pol. 2021 .
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