Ameliorative effects of inulin on non alcoholic fatty liver disease associated with type 2 diabetes mellitus in obese women

Authors

  • Mariam Atef Analytical Chemistry Department, Egyptian Drug Authority, Control & Operations Sector, Giza, Egypt
  • Dina Abo El-Matty Biochemistry Department Faculty of Pharmacy Suez Canal University, Ismailia, Egypt
  • Dawoud Fakhry Habib Medical Biochemistry Department, National Research Centre, Giza, Egypt
  • Wassef Girgiss Nicola Internal Medicine, Endocrinology & Metabolism-Department of Complementary Medicine, National Research Centre, Giza, Egypt
  • Samy Saleh Biochemistry Department Faculty of Pharmacy Suez Canal University, Ismailia, Egypt
  • Hanan Hanna Chemical pathology, Pharos University, Alexandria, Egypt

Abstract

Objectives: This study investigated the effects of inulin at the level of 3 grams twice daily for 4 weeks in alleviating the complications associated with NAFLD. Also, we want to evaluate the role of serum irisin in NAFLD. Subjects and methods: Six grams of inulin fructans were given daily for each of the fifty obese type 2 diabetic female patients with NAFLD for a period of four weeks. Parameters estimated pre and post administration of inulin: fasting serum glucose, fasting serum insulin, fasting serum liver aminotransferases (AST, ALT) & Gamma glutamyltransferase (γ-GT) and serum irisin. HOMA Insulin Resistance (IR), AST/ALT ratio and Fatty Liver Index (FLI) were calculated. Results: Administration of inulin induced a significant reduction infasting serum glucose, insulin, insulin resistance, lipid profile (Cholesterol & triglycerides), aminotransferase enzymes (AST & ALT) and Fatty Liver Index (FLI). Otherwise, serum HDL-cholesterol and serum irisin levels showed a significant increase after inulin intake. Serum irisin negatively correlated with diabetes mellitus parameters, Total cholesterol, triglycerides and liver enzymes aminotransferases (AST & ALT), but correlated directly with HDL-C. Conclusions: Inulin fructans, improve liver function so may reduce the risk NAFLD associated with insulin resistance. Inulin seems to be a valuable add on therapy for hepatic steatosis amelioration. Irisin is considered as a new biochemical marker for diagnosis of NAFLD and might have an essential role in preventing the hepatic steatosis and attenuating its progression to steatohepatitis.

Keywords:

Inulin, NAFLD, Obesity, Liver fat index, Irisin, Liver enzymes

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Published

14-05-2020
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How to Cite

Mariam Atef, Dina Abo El-Matty, Dawoud Fakhry Habib, Wassef Girgiss Nicola, Samy Saleh, and Hanan Hanna. “Ameliorative Effects of Inulin on Non Alcoholic Fatty Liver Disease Associated With Type 2 Diabetes Mellitus in Obese Women”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 7, no. 2, May 2020, pp. 06-16, https://jipbs.com/index.php/journal/article/view/387.

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Research Article