Ameliorative effects of inulin on non alcoholic fatty liver disease associated with type 2 diabetes mellitus in obese women


  • Mariam Atef Analytical Chemistry Department, Egyptian Drug Authority, Control & Operations Sector, Giza, Egypt
  • Dina Abo El-Matty Biochemistry Department Faculty of Pharmacy Suez Canal University, Ismailia, Egypt
  • Dawoud Fakhry Habib Medical Biochemistry Department, National Research Centre, Giza, Egypt
  • Wassef Girgiss Nicola Internal Medicine, Endocrinology & Metabolism-Department of Complementary Medicine, National Research Centre, Giza, Egypt
  • Samy Saleh Biochemistry Department Faculty of Pharmacy Suez Canal University, Ismailia, Egypt
  • Hanan Hanna Chemical pathology, Pharos University, Alexandria, Egypt


Objectives: This study investigated the effects of inulin at the level of 3 grams twice daily for 4 weeks in alleviating the complications associated with NAFLD. Also, we want to evaluate the role of serum irisin in NAFLD. Subjects and methods: Six grams of inulin fructans were given daily for each of the fifty obese type 2 diabetic female patients with NAFLD for a period of four weeks. Parameters estimated pre and post administration of inulin: fasting serum glucose, fasting serum insulin, fasting serum liver aminotransferases (AST, ALT) & Gamma glutamyltransferase (γ-GT) and serum irisin. HOMA Insulin Resistance (IR), AST/ALT ratio and Fatty Liver Index (FLI) were calculated. Results: Administration of inulin induced a significant reduction infasting serum glucose, insulin, insulin resistance, lipid profile (Cholesterol & triglycerides), aminotransferase enzymes (AST & ALT) and Fatty Liver Index (FLI). Otherwise, serum HDL-cholesterol and serum irisin levels showed a significant increase after inulin intake. Serum irisin negatively correlated with diabetes mellitus parameters, Total cholesterol, triglycerides and liver enzymes aminotransferases (AST & ALT), but correlated directly with HDL-C. Conclusions: Inulin fructans, improve liver function so may reduce the risk NAFLD associated with insulin resistance. Inulin seems to be a valuable add on therapy for hepatic steatosis amelioration. Irisin is considered as a new biochemical marker for diagnosis of NAFLD and might have an essential role in preventing the hepatic steatosis and attenuating its progression to steatohepatitis.


Inulin, NAFLD, Obesity, Liver fat index, Irisin, Liver enzymes


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How to Cite

Mariam Atef, Dina Abo El-Matty, Dawoud Fakhry Habib, Wassef Girgiss Nicola, Samy Saleh, and Hanan Hanna. “Ameliorative Effects of Inulin on Non Alcoholic Fatty Liver Disease Associated With Type 2 Diabetes Mellitus in Obese Women”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 7, no. 2, May 2020, pp. 06-16,



Research Article