Effect of polymer concentration on drug release kinetics of Etodolac

Abstract

Natural as well as synthetic polymers have major role in formulation as well as drug release kinetics of drugs. Polymers like gellan gum, xanthan gum, tamarind xyloglucan and sodium CMC were used in present study for formulation of etodolac tablet. Polymer concentration and combination of multiple polymers was found to be have major effect on swelling index and drug release of sustained release matrix tablet of etodolac. This effect and contribution of individual polymer in drug release and swelling index was determined using Placket Burman Design and optimized using Factorial design.