Effect of polymer concentration on drug release kinetics of Etodolac
DOI:
https://doi.org/10.56511/JIPBS.2017.v4.i04.pp190-197Abstract
Natural as well as synthetic polymers have major role in formulation as well as drug release kinetics of drugs. Polymers like gellan gum, xanthan gum, tamarind xyloglucan and sodium CMC were used in present study for formulation of etodolac tablet. Polymer concentration and combination of multiple polymers was found to be have major effect on swelling index and drug release of sustained release matrix tablet of etodolac. This effect and contribution of individual polymer in drug release and swelling index was determined using Placket Burman Design and optimized using Factorial design.
Keywords:
Polymers, Drug release, Swelling IndexDownloads
References
Y. Dong, S.S. Feng: Poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles prepared by high pressure homogenization for paclitaxel chemotherapy. Int. J. Pharm. 2007; 342:208 – 214.
K. Dillen, J. Vandervoort, G. Van den Mooter, L. Verheyden, A. Ludwig: Factorial design, physicochemical characterisation and activity of ciprofloxacin-PLGA nanoparticles. Int. J. Pharm. 2004; 275:171 – 187.
C. Qian, D.J. Mcclements: Formation of nanoemulsions stabilized by model food-grade emulsifiers using high-pressure homogenization: Factors affecting particle size, Food Hydrocoll. 2011; 4:1000 – 1008.
S.N. Maindarkar, P. Bongers, M. A. Henson: Predicting the effects of surfactant coverage on drop size distributions of homogenized emulsions. Chem. Eng. Sci. 2013; 89:102 – 114.
R. Vehring, W.R. Foss, D. Lechuga-Ballesteros: Particle formation in spray drying. J. Aerosol Sci. 2007; 38:728 – 746.
K. Masters: Spray Drying: An Introduction to Principles, Operational Practice, and Applications. K. Masters, George Godwin Limited, 1976.
A Lamprecht, H. Rodero Torres, U. Schäfer, C.M. Lehr: Biodegradable microparticles as a two-drug controlled release formulation: a potential treatment of inflammatory bowel disease. J. Control. Release 2000; 69:445 – 454.
J. Herrmann, R. Bodmeier: Somatostatin containing biodegradable microspheres prepared by a modified solvent evaporation method based on W/O/W-multiple emulsions. Int. J. Pharm. 1995; 126:129 – 138.
H.S. Yoo: Preparation of biodegradable polymeric hollow microspheres using O/O/W emulsion stabilized by Labrafil ®, Colloids Surf. B Biointerfaces 2006; 52:47 – 51.
D. Chognot, M. Léonard, J.-L. Six, E. Dellacherie: Surfactive water soluble copolymers for the preparation of controlled surface nanoparticles by double emulsion/solvent evaporation. Colloids Surf. B. Biointerfaces 2006; 51:86 – 92.
F. Puisieux, A. Gulik, P. Couvreur: Characterization of V3 BRU peptideloaded small PLGA microspheres prepared by a (Wl/O)W2 emulsionsolvent evaporation method Int. J. Pharm. 1994; 111:137 – 145.
J. Herrmann, R. Bodmeier: The effect of particle microstructure on the somatostatin release from poly(lactide) microspheres prepared by a W/O/W solvent evaporation method. J. Control. Release 1995; 36:63 – 71.
I.D. Rosca, F. Watari, M. UO: Microparticle formation and its mechanism in single and double emulsion solvent evaporation. J. Control Release 2004; 99:271 – 280.
K. Dillen, J. Vandervoort, G. Van den Mooter, A. Ludwig: Evaluation of ciprofloxacin-loaded Eudragit RS100 or RL100/PLGA nanoparticles. Int. J. Pharm. 2006; 314:72 – 82.
N. Ubrich, C. Schmidt, R. Bodmeier, M. Hoffman, P. Maincent: Oral evaluation in rabbits of cyclosporin-loaded Eudragit RS or RL nanoparticles. Int. J. Pharm. 2005; 288:169 – 175.
R. Bodmeier, H. Chen, P. Tyle, P. Jarosz: Pseudoephedrine HCl microspheres formulated into an oral suspension dosage form. J. Control Release 1991; 15:65 – 77.
M. Li, O. Rouaud, D. Poncelet: Microencapsulation by solvent evaporation: state of the art for process engineering approaches. Int. J. Pharm. 2008; 363:26 – 39.
S. Freitas, H.P. Merkle, B. Gander: Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology. J. Control Release 2005; 102:313 – 332.
J. McGinity, P. O’Donnell: Preparation of microspheres by the solvent evaporation technique. Adv. Drug Deliv. Rev. 1997; 28:25 – 42.
T. Niwa, H. Takeuchi, T. Hino, N. Kunou, Y. Kawashima: Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with D,Llactide/ glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior. J. Control. Release 1993; 25:89 – 98.
H. Hamishehkar, J. Emami, A.R. Najafabadi, K. Gilani, M. Minaiyan, H. Mahdavi, et al.: The effect of formulation variables on the characteristics of insulin-loaded poly(lactic-co-glycolic acid) microspheres prepared by a single phase oil in oil solvent evaporation method. Colloids Surf. B. Biointerfaces 2009; 74:340 – 349.
Y. Han, H. Tian, P. He, X. Chen, X. Jing: Insulin nanoparticle preparation and encapsulation into poly(lactic-co-glycolic acid) microspheres by using an anhydrous system. Int. J. Pharm. 2009; 378:159 – 66.
J.B. Naik, A.B. Lokhande, S. Mishra, R. D. Kulkarni: Development of sustained release micro/nanoparticles using different solvent emulsification technique: A review. Int J Pharm Bio Sci. 2012; 3:573 – 590.
E. Polard, P. Le Corre, F. Chevanne, R.L. Le Verge: In vitro and in vivo evaluation of polylactide and polylactide-co-glycolide microspheres of morphine for site-specific delivery. Int. J. Pharm. 1996; 134: 37 – 46.
M. Tunçay, S. Cali, H.S. Ka, M.T. Ercan, I. Peksoy, A.A. Hincal: In vitro and in vivo evaluation of diclofenac sodium loaded albumin microspheres. J. Microencapsul. 2000; 17:145 – 155.
T. Freytag, a Dashevsky, L. Tillman, G.E. Hardee, R. Bodmeier: Improvement of the encapsulation efficiency of oligonucleotidecontaining biodegradable microspheres. J. Control Release 2000; 69:197 – 207.
Z. Hu, Y. Liu, W. Yuan, F. Wu, J. Su, T. Jin: Effect of bases with different solubility on the release behavior of risperidone loaded PLGA microspheres. Colloids Surf. B. Biointerfaces 2011; 86:206 – 211.
P. Valot, M. Baba, J.-M. Nedelec, N. Sintes-Zydowicz: Effects of process parameters on the properties of biocompatible ibuprofen-loaded microcapsules. Int. J. Pharm. 2009; 369:53 – 63.
T. Kristmundsdóttir: Release of diltiazem from Eudragit microparticles prepared by spray-drying. Int. J. Pharm. 1996; 137:159 – 165.
M. Hans, A. Lowman: Biodegradable nanoparticles for drug delivery and targeting. Curr. Opin. Solid State Mater. Sci. 2002; 6: 319 – 327.
Published
How to Cite
Issue
Section
Copyright (c) 2017 M. P. Shirbhate, M. J. Chavan
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Journal of Innovations in Pharmaceutical and Biological Sciences is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on a work at