Preclinical evaluation of standardized anti-diabetic herbal formulation (ADC-05)

Authors

  • Tapas Kumar Sur Department of Pharmacology, Institute of Post Graduate Medical Education & Research 244 B, AJC Bose Road, Kolkata 700020, West Bengal, India
  • Avijit Hazra Department of Pharmacology, Institute of Post Graduate Medical Education & Research 244 B, AJC Bose Road, Kolkata 700020, West Bengal, India

Abstract

ADC-05 a new formulation was prepared with nine standardized herbal extracts for anti-diabetic actions to find out the anti-diabetic potentialities in experimental animals as well as explore its potential mode of actions. ADC-05 exhibited rich in phenolics and showed DPPH antioxidant scavenging actions. Moreover, it showed a-amylase and α-glucosidase inhibition dose dependently. ADC-05 did not showed any signs of toxicity or mortality up to 2.0 g/kg per oral dose in mice. Oral administration of ADC-05 at the dose of 100 mg/kg and 200 mg/kg significantly declined the fasting blood sugar level within 2 h and 14 days consecutive treatments, similar to Glibenclamide in Streptozotocin induced hyperglycemic rats. In conclusion it may infer that new formulation ADC-05 has antidiabetic potentialities in rats.

Keywords:

Diabetes, herbs, glucose, antioxidant, α-amylase, α-glucosidase

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Published

05-04-2017
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How to Cite

Sur, T. K., and Avijit Hazra. “Preclinical Evaluation of Standardized Anti-Diabetic Herbal Formulation (ADC-05)”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 4, no. 2, Apr. 2017, pp. 12-16, https://jipbs.com/index.php/journal/article/view/219.

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Section

Research Article