Preclinical evaluation of standardized anti-diabetic herbal formulation (ADC-05)
DOI:
https://doi.org/10.56511/JIPBS.2017.v4.i02.pp12-16Abstract
ADC-05 a new formulation was prepared with nine standardized herbal extracts for anti-diabetic actions to find out the anti-diabetic potentialities in experimental animals as well as explore its potential mode of actions. ADC-05 exhibited rich in phenolics and showed DPPH antioxidant scavenging actions. Moreover, it showed a-amylase and α-glucosidase inhibition dose dependently. ADC-05 did not showed any signs of toxicity or mortality up to 2.0 g/kg per oral dose in mice. Oral administration of ADC-05 at the dose of 100 mg/kg and 200 mg/kg significantly declined the fasting blood sugar level within 2 h and 14 days consecutive treatments, similar to Glibenclamide in Streptozotocin induced hyperglycemic rats. In conclusion it may infer that new formulation ADC-05 has antidiabetic potentialities in rats.
Keywords:
Diabetes, herbs, glucose, antioxidant, α-amylase, α-glucosidaseDownloads
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