Optimization of feed composition for spray drying of probiotics


  • Lohiya G. K. Department of Pharmaceutics, Gurunanak College of Pharmacy, Nagpur, India
  • Avari J.G. Department of Pharmaceutical Science, R.T.M. Nagpur University, Nagpur, India


In this study, we are chosen lactobacilli acidophilus as probiotics and trying to optimize the feed composition to get the maximum protection to it during spray drying. Probiotics cell suspension keeps at 1%w/v on dry base and the three different protecting agents selected were microcrystalline cellulose, Lactose and skimmed milk. All were used at three different concentrations 5%w/v, 10%w/v and 15%w/v. Also MCC and skimmed milk were used in different combination. The results were analyzed for percent cell viability, percent recovery and moisture content as well as for powder properties. Maximum percent cell of 82% obtained with 15%w/v SM followed by 80% with 10%w/v SM. Lowest cell viability of 48% was obtained with 5%w /v MCC. Maximum recovery of 80% obtained with 5%w/v MCC and also gives the lowest moisture content of 3.3 percent. The spray dried samples were also analyzed for powder properties. Overall MCC and skimmed milk combination were found to be suitable for spray drying of probiotics.


spray drying, probiotics, lactobacilli acidophilus


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How to Cite

Lohiya G. K., and Avari J.G. “Optimization of Feed Composition for Spray Drying of Probiotics”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 3, no. 1, Jan. 2016, pp. 154-61, https://jipbs.com/index.php/journal/article/view/123.



Research Article