UV Spectrophotometric Method Development and Validation for quantitative estimation of Nizatidine

Authors

  • Rahul Kumar Garg Pacific College of Pharmacy, Udaipur (Rajasthan) -313004, India
  • Indrajeet Singhvi Pacific College of Pharmacy, Udaipur (Rajasthan) -313004, India

Abstract

A novel, safe and sensitive method of spectrophotometric estimation in UV-region has been developed for the assay of Nizatidine in tablet formulation. The method was developed are based on the solubility of Nizatidine in 0.1 N HCl (pH 1.2). The drug showed maximum absorbance (λmax) at 325 nm and linearity (Lambert Beer’s Range) was found in concentration range of 5-40 μg/ml and the standard curve equation was found to be  y = 0.025x + 0.005 and R2 value 0.998. The results of analysis were validated statistically and by recovery studies. All the parameters of the analysis were chosen according to ICH [Q2(R1)] guidelines.

Keywords:

Nizatidine, Buffer pH 1.2, UV method, Validation

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Published

06-07-2015
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How to Cite

Garg, R. K., and I. Singhvi. “UV Spectrophotometric Method Development and Validation for Quantitative Estimation of Nizatidine”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 2, no. 3, July 2015, pp. 333-6, https://jipbs.com/index.php/journal/article/view/74.

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Research Article