UV Spectrophotometric Method Development and Validation for quantitative estimation of Nizatidine
DOI:
https://doi.org/10.56511/JIPBS.2015.v2.i03.pp333-336Abstract
A novel, safe and sensitive method of spectrophotometric estimation in UV-region has been developed for the assay of Nizatidine in tablet formulation. The method was developed are based on the solubility of Nizatidine in 0.1 N HCl (pH 1.2). The drug showed maximum absorbance (λmax) at 325 nm and linearity (Lambert Beer’s Range) was found in concentration range of 5-40 μg/ml and the standard curve equation was found to be y = 0.025x + 0.005 and R2 value 0.998. The results of analysis were validated statistically and by recovery studies. All the parameters of the analysis were chosen according to ICH [Q2(R1)] guidelines.
Keywords:
Nizatidine, Buffer pH 1.2, UV method, ValidationDownloads
References
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Copyright (c) 2015 Rahul Kumar Garg, Indrajeet Singhvi
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Journal of Innovations in Pharmaceutical and Biological Sciences is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on a work at