A Review on Progeria

Authors

  • Deepu S D Nazareth College of pharmacy, Othera, Thiruvalla, India
  • Ajin Sam Nazareth College of pharmacy, Othera, Thiruvalla, India
  • Vishnu R Nair Nazareth College of pharmacy, Othera, Thiruvalla, India
  • Tony Kuriakose Nazareth College of pharmacy, Othera, Thiruvalla, India
  • Jiju V Nazareth College of pharmacy, Othera, Thiruvalla, India
  • Santhosh M Mathews Nazareth College of pharmacy, Othera, Thiruvalla, India

Abstract

Progeria (Hutchinson–Gilford progeria syndrome, HGPS, progeria syndrome) is an extremely rare genetic disorder wherein symptoms resembling aspects of aging are manifested at a very early age. Classical Hutchinson–Gilford progeria syndrome is usually caused by a sporadic mutation taking place during the early stages of embryo development. It is almost never passed on from affected parent to child, as affected children rarely live long enough to have children themselves. There have been only two cases in which a healthy person was known to carry the LMNA mutation that causes progeria. These carriers were identified because they passed it on to their children. Progeria may be a de novo dominant trait. It develops during cell division in a newly conceived zygote or in the gametes of one of the parents. It is caused by mutations in the LMNA (lamin A proteingene on chromosome 1; the mutated form of lamin A is commonly known as progerin.

Keywords:

: Progeria, lamin A, HGPS, Morpholinos, Prelamin A

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Published

06-07-2015
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How to Cite

D, D. S., A. Sam, V. R. Nair, T. Kuriakose, J. V, and S. M. Mathews. “A Review on Progeria”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 2, no. 3, July 2015, pp. 261-5, https://jipbs.com/index.php/journal/article/view/67.

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Review Article