Antihyperglycemic effect of Woodfordia fruticosa (Linn) Kurz in STZ-induced diabetic rats

Abstract

The present study was carried out to investigate Woodfordia fruticosa Linn (Kurz) for pharmacological screening of flower extract of the plant in streptozotocin induced diabetic rats. Woodfordia fruticosa Linn (Kurz) was collected in the month of January, from kumta district. It was authenticated by renowned botanist. Authenticated plant material was evaluated morphologically and microscopically. Air dried powdered flower of the plant was extracted successively using alcohol as solvent and water extract by maceration process.  Acute oral toxicity studies was carried out and two non lethal doses 100 and 200 mg/kg p.o was selected for the Antihyperglycemic activity. To confirm the anti-diabetic activity of the plant the OGTT were carried out in normal rats, followed by various biochemical parameters such as Serum insulin (SI), serum triglyceride (TG), Serum total cholesterol (TC), HDL-c, VLDL-c, LDL-c, TC/HDL-cThe WFA and WFE extracts (100 mg/kg) significantly reduced the SG levels, normalization of lipid profile and increased insulin levels in diabetic treated rats. Higher dose of WFE and WFA (200 mg/kg) was more effective than the lower dose and the results was comparable with diabetic control as well as standard drug Glibenclamide treated group. In this study an attempt was made to provide scientific backup to the traditional claim. Since the results exhibited a significant anti-diabetic activity in albino rats, so the traditional use of Woodfordia fruticosa Linn may be justified for the Antihyperglycemic activity