Green chemistry approach for the synthesis of 2,4,5-triaryl-1H-imidazole derivatives using lemon juice as a bio-catalyst

Authors

  • Firoz A. Kalam Khan School of Pharmacy, Anjuman-I-Islam’s Kalsekar Technical Campus, Navi Mumbai 410206 (MS), India.
  • Kaif A. Shaikh School of Pharmacy, Anjuman-I-Islam’s Kalsekar Technical Campus, Navi Mumbai 410206 (MS), India.
  • Jeehan M. Choudhary School of Pharmacy, Anjuman-I-Islam’s Kalsekar Technical Campus, Navi Mumbai 410206 (MS), India.
  • Sirguroh M. Ilyas Khan School of Pharmacy, Anjuman-I-Islam’s Kalsekar Technical Campus, Navi Mumbai 410206 (MS), India.
  • Laxmi G. Shalgar School of Pharmacy, Anjuman-I-Islam’s Kalsekar Technical Campus, Navi Mumbai 410206 (MS), India.
  • Amjad Ali Department of Pharmaceutical Chemistry and Quality Assurance, Oriental College of Pharmacy, Navi Mumbai 400 705, (MS) India.
  • Sayyed Mateen Department of Pharmacology, Oriental College of Pharmacy, Navi Mumbai 400 705, (MS) India.

DOI:

https://doi.org/10.56511/JIPBS.2022.9403

Abstract

The use of green chemistry is crucial for organic synthesis to protect the environment from hazardous and toxic substances. Lemon juice is a promising candidate for a green chemistry catalyst because it is widely available, inexpensive, biodegradable, and non-toxic. This study reports a simple and highly effective one-pot synthesis of 2,4,5-triaryl-1H-imidazole derivatives 4(a-l) using lemon juice as a biocatalyst. The method involves a three-component condensation reaction of benzil, aromatic aldehydes, and ammonium acetate in ethanol using lemon juice as a catalyst, and offers several benefits such as short reaction time, easy work-up, low-cost catalyst, and good yields. Additionally, in silico prediction of ADME properties suggests that the synthesized compounds 4(a-l) have the potential to exhibit favourable oral drug-like properties.

Keywords:

Lemon juice, One-pot three-component reaction, 2,4,5-triaryl-1H-imidazoles, In silico ADME

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Published

05-10-2022
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How to Cite

Khan, F. A. K., Kaif A. Shaikh, Jeehan M. Choudhary, S. M. I. Khan, Laxmi G. Shalgar, Amjad Ali, and Sayyed Mateen. “Green Chemistry Approach for the Synthesis of 2,4,5-Triaryl-1H-Imidazole Derivatives Using Lemon Juice As a Bio-Catalyst”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 9, no. 4, Oct. 2022, pp. 13-17, doi:10.56511/JIPBS.2022.9403.

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Section

Research Article