A flavone compound isolated from the stem bark of Butea frondosa: A broad spectrum bactericide especially active on Bacillus
DOI:
https://doi.org/10.56511/JIPBS.2020.v7.i03.pp59-63Abstract
The Quinoline compound isolated from the ethyl acetate fraction of B. Frondosa stem bark showed some significant antimicrobial activity when tested against 106 different bacterial strains belonging to 9 different genera of both Gram-positive and Gram- negative. Minimuim inhibitory concentration of the drug were measured using an agar dilution technique. Twenty four of 36 strains of Staphylococcus aureus were inhibited by 100-200 mg/l of drug. This drug also inhibited strains of Bacillus spp, Shigella spp, Salmonella spp and Pseudomonas spp at a concentration of 100-400 mg/l. Other bacteria including Escherichia coli, Vibrio cholerae and V. parahaemolyticus were moderately sensitive to drug. In the in vivo studies this compound offered significant protection to swiss albino mice at a concentration of 80 µg /mouse (P<0.001) when challenged with 50 median lethal dose of Salmonella typhimurium NCTC 74
Keywords:
Butea frondosa, Quinoline : Broad spectrum bactericide, Antimicrobial activityDownloads
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