A flavone compound isolated from the stem bark of Butea frondosa: A broad spectrum bactericide especially active on Bacillus

Authors

  • Jiten Mishra Roland Institute of Pharmaceutical Sciences, Berhampur, Orissa-760010, India
  • Digambar Bisoi Sivananda College of Pharmacy, Berhampur, Orissa-760010, India
  • Nityashree Mohapatra Sivananda College of Pharmacy, Berhampur, Orissa-760010, India

Abstract

The Quinoline compound isolated from the ethyl acetate fraction of B. Frondosa stem bark showed some significant antimicrobial activity when tested against 106 different bacterial strains belonging to 9 different genera of both Gram-positive and Gram- negative. Minimuim inhibitory concentration of the drug were measured using an agar dilution technique. Twenty four of 36 strains of Staphylococcus aureus were inhibited by 100-200 mg/l of drug. This drug also inhibited strains of Bacillus spp, Shigella spp, Salmonella spp and Pseudomonas spp at a concentration of 100-400 mg/l. Other bacteria including Escherichia coli, Vibrio cholerae and V. parahaemolyticus were moderately sensitive to drug. In the in vivo studies this compound offered significant protection to swiss albino mice at a concentration of  80 µg /mouse (P<0.001) when challenged with 50 median lethal dose of Salmonella typhimurium NCTC 74

Keywords:

Butea frondosa, Quinoline : Broad spectrum bactericide, Antimicrobial activity

Downloads

Download data is not yet available.

Published

16-08-2020
Statistics
40 Views | 40 Downloads

How to Cite

Jiten Mishra, Digambar Bisoi, and Nityashree Mohapatra. “A Flavone Compound Isolated from the Stem Bark of Butea Frondosa: A Broad Spectrum Bactericide Especially Active on Bacillus”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 7, no. 3, Aug. 2020, pp. 59-63, https://jipbs.com/index.php/journal/article/view/394.

Issue

Section

Research Article