Shrewd natural and synthetic biodegradable polymers for targeted sustain and controlled release formulation
DOI:
https://doi.org/10.56511/JIPBS.2014.v1.i03.pp102-116Abstract
In recent years there has been increase in interest of biodegradable polymers. Biodegradability depends not only on the origin of the polymer but also on its chemical structure and the environmental degrading conditions. Two classes of biodegradable polymers can be distinguished: synthetic or natural polymers. There are polymers produced from feedstocks derived either from petroleum resources (non renewable resources) or from biological resources (renewable resources).Natural and synthetic Biodegradable polymers are extensively used for the development of various dosage forms. Biodegradable polymers are generally hydrophilic in nature and have limited swelling characteristic in acidic ph. Linear polysaccharides remains intact in stomach and small intestine so they can be use for controlled release formulation and the bacteria of human colon degrades them and thus make them potentially useful in colon targeted drug delivery systems. Various drug delivery systems have been designed that deliver the drug quantitatively to the colon and then trigger the release of drug. This review will cover different types of polymers which can be used in formulation of sustain, controlled and colon targeted drug delivery systems.
Keywords:
Biodegradable polymers, sustain delivery, colon targeted delivery, controlled deliveryDownloads
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