UV spectrophotometric assay of Diclofenac sodium available brands
DOI:
https://doi.org/10.56511/JIPBS.2014.v1.i03.pp92-96Abstract
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). A efficient, simple and least time consuming spectrophotometric method for the assay of diclofenac sodium has been developed. Comparison of assay of four different brands of diclofenac sodium (Dicloran, Defnac, Artifin, voltral) has also been done available in public medical store of Karachi, Pakistan. The assay is based on the ultraviolet UV absorbance maxima at about 276nm wavelength of diclofenac sodium using water as solvent. A sample of drug was dissolved in water to produce a solution containing diclofenac sodium. Similarly, a sample of ground tablets of different brand were dissolved in water and various dilutions were made. The absorbance of sample preparation was measured at 276nm against the solvent blank and the assay was determined by comparing with the absorbance of available brand. The method can be applied for the routine QC quantitation of diclofenac sodium in tablet formulation and active. Our results reveals that among all the four brands of diclofenac sodium (Dicloran, Defnac, Artifin, voltral) Defnac and voltral shows highest percentage assay 104% and Dicloran shows lowest value for percentage assay 96.4% , while artifin shows a percentage assay of 98.6%.
Keywords:
Diclofenac, percentage assay, UV spectrophotometer, ANOVADownloads
References
Va ne JR. Inhibition of prostaglandin synthesis as a mechanism o f action for aspirin - like drugs. Nat New Biol. 1971; 231 :232 – 235.
Morita I. Distinct functions of COX - 1 and COX - 2. Prostaglandins Other Lipid Mediat. 2002; 68 (69):165 – 75.
Huili Z., et al.2011 S-diclofenac Protects against Doxorubicin-Induced Cardiomyopathy in Mice via Ameliorating Cardiac Gap Junction Remodeling. 2011; 6(10): e26441.
Durairaj C, Shah JC, Senapati S, Kompella UB. Prediction of vitreal half - life based on drug physicochemical properties: quantitative structure - pharmacokinetic relationships (QSPKR). Pharm Res. 2009; 26 :1236 – 1260s
Turner S, Longworth A, Nunn AJ, Choonara I. Unlicensed and off label drug use in paediatric wards: prospective study. BMJ. 1998;316:343 – 5.
Conroy S, Peden V. Unlicensed and off label analgesic use in paediatric pain management. Paediatr Anaesth.2001;11:431 – 6.
Eva G . et al. New Aspects of an Old Drug – Diclofenac Targets MYC and Glucose Metabolism in Tumor Cells .2013;8(7): e66987
Safila Naveed, Huda Kafeel and Ramsha Rukh (2014) Spectrophotometric method for the estimation of Ciprofloxacin in different medium. International Journal of Pharmaceutical Research & Drug Development 1:1:27-30
Safila Naveed (2014) Simple UV spectrophotometric assay of Atorvastatin API formulation and their comparative study, Global Journal of Medical Research .14(2):35-38. https://globaljournals.org/GJMR_Volume14 /4-Simple-UV-Spectrophotometric Assay.pdf
Naveed Safila. Qamar Fatima., Sarwer Ghulam., (2014) Percentage assay of metformin in different medium using UVspectrophotometer BPJ0000130 - World Research Journal of Organic Chemistry Volume : 2 Issue : 1, 12 - 1 4
Huma Dilshad, Safila Naveed and Baqir Naqvi (2013) Assay of new formulations of isosorbide mononitrate by using uv spectrophotometer : BPJ0000115 - World Research Journal of Medicine Volume : 1 Issue : 1, pg9 - 10
Huma Dilshad, Safila Naveed and Ghulam Sarwar (2014) Simple spectrophotometric assay of available brands of Acetaminophen tablets and their comparative study Journal of pharmacy and pharmaceutical sciences Volume 2, Issue 1,1 - 4
Safila Naveed and Fatima Qamar (2014) A simple assay of Esomeprazole Using UV spectrophotometer The Global Journal of Pharmaceutical Research (TGJPR) 3(2); 1921-25, http://www.tgjpr.com/viewarticle.php?id=3433
Safila Naveed and Fatima Qamar (2014) Simple UV spectrophotometric assay of Mefenamic acid International Journal of Pharma Sciences and Research (IJPSR) ,5(7):364-366 .http://www.ijpsr.info/ijpsrv5n7.php
Safila Naveed, Shabana Naz Shah, Fatima Qamar , Nimra Waheed, and Safeena Nazeer, (2014) simple uv spectrophotometric assay of new formulation gentamycin J App Pharm Vol. 6; Issue 4: 407-410
Safila Naveed, Shabana Naz Shah, Fatima Qamar , Nimra Waheed, and Safeena Nazeer, (2014) Simple UV spectrophotometric assay of Lincomycin, IJPRDD, 1 (2),10-12.
Safila Naveed * and Amber Nawab (2014) Assay of LVFX (levofloxacin) in different formulation by UV spectroscopy IJPRDD, 1 (2), 13-16.
Safila Naveed and Fatima Qamar (2014) Simple UV spectrophotometric assay of Metronidazole Open Access Library Journal, 1e614. http://dx.doi.org/10.4236/oalib.1100614.
Published
How to Cite
Issue
Section
Copyright (c) 2014 Safila Naveed, Fatima Qamar
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Journal of Innovations in Pharmaceutical and Biological Sciences is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on a work at