Exploring patient’s perceptions of cancer chemotherapy side effects

Authors

  • Wesam Abdel-Razaq King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, College of Pharmacy, Ministry of National Guard Health Affairs, Riyadh 11481, Saudi Arabia
  • Mohammed Alzahrani King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, College of Pharmacy, Ministry of National Guard Health Affairs, Riyadh 11481, Saudi Arabia
  • Rami Bustami King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, College of Pharmacy, Ministry of National Guard Health Affairs, Riyadh 11481, Saudi Arabia
  • Yousef Alolah Pharmaceutical Care Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh 11426, Saudi Arabia
  • Mohammed Almutlag King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, College of Pharmacy, Ministry of National Guard Health Affairs, Riyadh 11481, Saudi Arabia

DOI:

https://doi.org/10.56511/JIPBS.2017.v4.i03.pp09-14

Abstract

Cancer chemotherapy has been always associated with a bad reputation among healthcare providers, patients and their families mainly due to their associated side effects. The objectives of the present study were to identify and rank the incidence of the most disturbing cancer chemotherapy side effects and to assess patient’s perceptions of these side effects as the treatment progresses. A cross-sectional interview-based survey was conducted in the Medical Oncology Outpatient clinic at King Abdulaziz Medical City, Riyadh, Saudi Arabia. The sample size realized as 100 participants and they reported mucositis, nausea or vomiting and fatigue as the most troubling side effects followed by hair loss, dry mouth, unpleasant taste and constipation.  However, the rank of these side effects changed as they proceeded through their treatments. The majority of the disturbing side effects significantly diminished in most patients. However, fatigue significantly increased as the chemotherapy progressed, which could limit the participants’ ability to work or perform everyday activities of life. Although most of the participants expressed a high level of satisfaction of the quality of information they received prior to their cancer treatment, they were concerned about the distressing nature of the treatment and the potential deterioration in their quality of life due to the chemotherapy side effects. It is therefore important to improve the communication between health-care providers and patients to identify those side effects of concern to patients to reduce their expected burden and ultimately succeed in achieving the cancer therapy outcome

Keywords:

Cancer, Chemotherapy, Side effects, Fatigue, Perceptions

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References

Teker F, Demirag G, Erdem D, Kemal Y, Yucel I: Quality of life in colorectal cancer patients during chemotherapy in the era of monoclonal antibody therapies. Journal of Balkan Union of Oncology 2015; 20 (2):443-451.

Roncolato F, O'Connell R, Buizen L, Joly F, Lanceley A, Hilpert F, Okamoto A, Aotani E, Pignata S, Donnellan PP, Oza AM, AvallLundqvist E, Berek JS, Sjoquist KM, Gillies K, Stockler MR, King MT, Friedlander M, GCIG Symptom Benefit group: Baseline quality of life (QOL) as a predictor of stopping chemotherapy early, and of overall survival, in platinum-resistant/refractory ovarian cancer (PRROC): The GCIG symptom benefit study (SBS). Journal of Clinical Oncology 2016; 34 (15_suppl):5508.

Saudi Cancer Registry (2007) Saudi Arabia Cancer Incidence and Survival Report 2007. Ministry of Health, Riyadh, Saudi Arabia.

Alshammari FD, Ahmed HG, Alawad GM, Alshammary MM, Alrashdi AG, Alrashedi SA, Alshammeri K, Eissa FZ: Epidemiological indicators of Cancer in North Saudi Arabia: A population-based Survey. International Journal of Biomedical Research 2015; 6 (9):5.

World Health Organization (2014) Noncommunicable Diseases (NCD) Country Profiles. http://www.who.int/nmh/countries/sau_en.pdf?ua=1 . Accessed 24/10 2016

Beaver K, Jones D, Susnerwala S, Craven O, Tomlinson M, Witham G, Luker KA: Exploring the decision-making preferences of people with colorectal cancer. Health Expectations 2005; 8 (2):103-113.

Henry NL, Somerfield MR, Abramson VG, Allison KH, Anders CK, Chingos DT, Hurria A, Openshaw TH, Krop IE: Role of Patient and Disease Factors in Adjuvant Systemic Therapy Decision Making for Early-Stage, Operable Breast Cancer: American Society of Clinical Oncology Endorsement of Cancer Care Ontario Guideline Recommendations. Journal of Clinical Oncology 2016; 34(19):23032311.

Fu AZ, Graves KD, Jensen RE, Marshall JL, Formoso M, Potosky AL: Patient preference and decision-making for initiating metastatic colorectal cancer medical treatment. Journal of cancer research and clinical oncology 2016; 142 (3):699-706.

Lennes IT, Temel JS, Hoedt C, Meilleur A, Lamont EB: Predictors of newly diagnosed cancer patients' understanding of the goals of their care at initiation of chemotherapy. Cancer 2013; 119 (3):691-699.

Gurung S, Pandey RA: Perception of Side Effects of Chemotherapy among Cancer Patients in B.P. Koirala Memorial Cancer Hospital Bharatpur, Nepal. Journal of College of Medical Sciences 2016; 11 (4):6.

Ramirez LY, Huestis SE, Yap TY, Zyzanski S, Drotar D, Kodish E: Potential chemotherapy side effects: what do oncologists tell parents? Pediatric blood & cancer 2009; 52 (4):497-502.

Wagland R, Richardson A, Armes J, Hankins M, Lennan E, Griffiths P: Treatment-related problems experienced by cancer patients undergoing chemotherapy: a scoping review. European journal of cancer care 2015; 24 (5):605-617.

Sun CC, Bodurka DC, Weaver CB, Rasu R, Wolf JK, Bevers MW, Smith JA, Wharton JT, Rubenstein EB: Rankings and symptom assessments of side effects from chemotherapy: insights from experienced patients with ovarian cancer. Supportive Care in Cancer 2005; 13 (4):219-227.

Van de Wetering MD, Schouten-van Meeteren NY: Supportive care for children with cancer. Seminars in oncology 2011; 38 (3):374-379.

Mustian KM, Devine K, Ryan JL, Janelsins MC, Sprod LK, Peppone LJ, Candelario GD, Mohile SG, Morrow GR: Treatment of Nausea and Vomiting During Chemotherapy. US Oncology & Hematology 2011; 7 (2):91-97.

Miller MM, Donald DV, Hagemann TM: Prevention and Treatment of Oral Mucositis in Children with Cancer. The Journal of Pediatric Pharmacology and Therapeutics 2012; 17 (4):340-350.

Henke M, Laszig R, Rube C, Schafer U, Haase KD, Schilcher B, Mose S, Beer KT, Burger U, Dougherty C, Frommhold H: Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial. The Lancet 2003; 362 (9392):1255-1260.

Warr DG: Chemotherapy-and cancer-related nausea and vomiting. Current Oncology 2008; 15 (Suppl 1):S4-9.

Colagiuri B, Dhillon H, Butow PN, Jansen J, Cox K, Jacquet J: Does assessing patients' expectancies about chemotherapy side effects influence their occurrence? Journal of pain and symptom management 2013; 46 (2):275-281.

Carelle N, Piotto E, Bellanger A, Germanaud J, Thuillier A, Khayat D: Changing patient perceptions of the side effects of cancer chemotherapy. Cancer 2002; 95 (1):155-163.

Akin S, Durna Z: A comparative descriptive study examining the perceptions of cancer patients, family caregivers, and nurses on patient symptom severity in Turkey. European Journal of Oncology Nursing 2013; 17 (1):30-37.

Poon KS, Un MK, Low XH, Cheung YT, Yap KY, Chan A: Impact of cancer-related fatigue on chemotherapy-induced nausea and vomiting in Asian cancer patients. Pharmacoepidemiology and drug safety 2013; 22 (12):1345-1351.

Lindley C, McCune JS, Thomason TE, Lauder D, Sauls A, Adkins S, Sawyer WT: Perception of chemotherapy side effects cancer versus noncancer patients. Cancer practice 1999; 7 (2):59-65.

Russo S, Cinausero M, Gerratana L, Bozza C, Iacono D, Driol P, Deroma L, Sottile R, Fasola G, Puglisi F: Factors affecting patient's perception of anticancer treatments side-effects: an observational study. Expert opinion on drug safety 2014; 13 (2):139-150.

Gumusay O, Cetin B, Benekli M, Gurcan G, Ilhan MN, Bostankolu B, Ozet A, Uner A, Coskun U, Buyukberber S: Factors Influencing Chemotherapy Goal Perception in Newly Diagnosed Cancer Patients. Journal of Cancer Education 2016; 31 (2):308-313.

Mulders M, Vingerhoets A, Breed W: The impact of cancer and chemotherapy: perceptual similarities and differences between cancer patients, nurses and physicians. European Journal of Oncology Nursing 2008; 12 (2):97-102.

Griffin AM, Butow PN, Coates AS, Childs AM, Ellis PM, Dunn SM, Tattersall MH: On the receiving end. V: Patient perceptions of the side effects of cancer chemotherapy in 1993. Annals of Oncology 1996; 7 (2):189-195.

Chouliara Z, Miller M, Stott D, Molassiotis A, Twelves C, Kearney N: Older people with cancer: perceptions and feelings about information, decision-making and treatment--a pilot study. European Journal of Oncology Nursing 2004; 8 (3):257-261.

Buiting HM, Rurup ML, Wijsbek H, van Zuylen L, den Hartogh G: Understanding provision of chemotherapy to patients with end stage cancer: qualitative interview study. British Medical Journal 2011; 342:d1933.

Published

05-07-2017
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How to Cite

Wesam Abdel-Razaq, Mohammed Alzahrani, Rami Bustami, Yousef Alolah, and Mohammed Almutlag. “Exploring patient’s Perceptions of Cancer Chemotherapy Side Effects”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 4, no. 3, July 2017, pp. 9-14, doi:10.56511/JIPBS.2017.v4.i03.pp09-14.

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Section

Research Article