Application of D-optimal mixture design for optimization of production parameters of fast and complete release dexamethasone amorphous solid dispersion tablet

Authors

  • Debabrata Ghosh Dastidar Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F Nilgunj Road, Panihati, Kolkata-700114, West Bengal, India
  • Suvam Ghosh Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F Nilgunj Road, Panihati, Kolkata-700114, West Bengal, India
  • Sumana Chatterjee Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F Nilgunj Road, Panihati, Kolkata-700114, West Bengal, India

Abstract

Dexamethasone is a glucocorticoid used widely worldwide for immunosuppressive treatment, allergies, bronchiolitis, and croup, among others. However poor aqueous solubility (0.1mg/ml) leads to poor rate of dissolution and hence limits its oral bioavailability. The objective of the present study was to optimize the level of different formulation components like PEG-6000 (hydrophilic carrier), lactose (filler) and starch (disintegrating agent) for the development of fast and complete release tablet of dexamethasone by 16 run D-Optimal Mixture Design. Dexamethasone was dispersed in PEG-6000 by Melt/Fusion method. FTIR and DSC study confirmed that dexamethasone was compatible with PEG-6000 and upon dispersion it became amorphous. Tablets were prepared by direct compression method. UV Spectrophotometric method was developed for estimation of dexamethasone. Both the response parameters Maximum % Drug Released (MDR) and Time to Maximum % Drug Release (TMDR) were best fitted to Cubic Mixture Model. The optimized tablet released 99.5% drug in 5 minute.

Keywords:

Solid dispersion, Dissolution, Solubility, Bioavailability, Oral absorption, Mixture Design

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Published

05-01-2017
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How to Cite

Dastidar, D. G., Suvam Ghosh, and Sumana Chatterjee. “Application of D-Optimal Mixture Design for Optimization of Production Parameters of Fast and Complete Release Dexamethasone Amorphous Solid Dispersion Tablet”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 4, no. 1, Jan. 2017, pp. 7-11, https://jipbs.com/index.php/journal/article/view/206.

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Research Article