Protective effect of Resveratrol against nephrotoxicity of nicotine in male rat: Antioxidant and histopathological approaches


  • Hayat A. A. Ismail Department of Biology, Faculty of Science, King Abdel Aziz University, Jeddah, Saudi Arabia


Background and Objective: The deleterious health effects of cigarette smoking are remaining the most important convertible risk factor for improving overall mortality. In addition to being a risk factor for kidney disease, there is strong evidence that demonstrating a role for cigarette smoking in the progression of chronic kidney disease (CKD). Nicotine can freely cross the biological membranes of body organs. Resveratrol is a compound which is a member of plant compounds called polyphenols which possess a free radical scavenger. The study aimed to evaluate the influence of Resveratrol (Res) in rat with Nicotine (Nic) induced nephrotoxicity, by evaluating the biochemical and histopathological changes. Methodology: The experiment was carried out on four groups of male rats as follows; The first group served as a control group, 2nd group was treated with Nic (2.5 mg kg-1) dissolved in physiological saline, 3rd group was received Res (20 mg Kg-1), 4th group was treated with combination of Nic (2.5 mg Kg-1) and Res (20 mg Kg-1). Results: The results indicated that Nic increased Uric acid, Urea, Creatinine, lipid peroxidation, TOS level and decrease the antioxidant enzymes as well as decrease the thiol and G6PD levels. A serious congestion, correlated with kidney was observed in Nic treatment and the role of Res in improving all the oxidative damage and the histopathological changes in kidney. In the light of the present results, it is evident that Res was able to reduce the nephrotoxic effect of Nic in male rats.


Nicotine, Resveratrol, Kidney, Oxidative stress, Histopathology


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How to Cite

Ismail, H. A. A. “Protective Effect of Resveratrol Against Nephrotoxicity of Nicotine in Male Rat: Antioxidant and Histopathological Approaches”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 3, no. 4, Oct. 2016, pp. 125-32,



Research Article