Antifungal agents and their action against dermatophytes: curious to know the facts

Abstract

Despite the improvement of antifungal therapies over the last 30 years, the development of antifungal resistance continues to be the major concern in clinical applications. Within 10 years the molecular mechanisms underlying this development were extensively unraveled. In this paper, a short summary of presently accessible antifungal, and their action against dermatophytes are elaborated. It seems that major mechanisms of resistance are essentially attributable to the release of antifungal resistance effectors genes. This release could be the consequence of point mutations occurring in transcriptional regulators of these effectors genes. Resistance may also follow the emergence of point mutations directly within the genes coding antifungal targets. Additionally, we tend to describe new possible ways, presently undertaken to discover various medical therapy targets and antifungal. Identification of new antifungal is achieved by a screening of natural or synthetic chemical compound collections. Discovery of new reputed antifungal targets performed through genome-wide approaches for much better understanding of the human pathogenic fungi biology. In this review, we will discuss different antifungal agents and their mechanism of action.