In-silico epitope based vaccine an excellent solution against Marburg virus

Authors

  • Anum Munir Department of Bioinformatics Government Post Graduate College Mandian, Abbottabad, Pakistan
  • Shumaila Azam Department of Bioinformatics Government Post Graduate College Mandian, Abbottabad, Pakistan. Department of Bioinformatics and bioscience, Capital University of Sciences and Technology, Islamabad, Pakistan
  • Maria Manzoor Department of Bioinformatics Government Post Graduate College Mandian, Abbottabad, Pakistan
  • Azhar Mehmood Department of Bioinformatics Government Post Graduate College Mandian, Abbottabad, Pakistan
  • G. Mujtaba Shah Department of Botany, Hazara University, Mansehra, Pakistan
  • Sahar Fazal Department of Bioinformatics and bioscience, Capital University of Sciences and Technology, Islamabad, Pakistan

Abstract

Marburg virus is the most deadly virus identified in the year 1967. MARV comprises a 19-KB noninfectious single-stranded RNA genome that encodes seven basic structural proteins. Right now; there is no accessible treatment or vaccine to cure the MARV disease since couples of immunizations are under clinical trial studies. Here the computational approach is used to predict multi-epitope vaccine candidates against this virus. Both T cell and B cell were checked for the peptides to confirm that they can bring both humoral and cell-mediated immunity. A 9mer T cell epitope ALSLTCAGI interacted with most of the MHC-I alleles and 10mer B cell epitope SLFVQAALYV was identified on antigenicity prediction. The regions; 7 – 12, 139 – 144 and 186 – 191 amino acid residues were more accessible as B cell epitopes. The predicted epitope docked with the human HLA:*A0201. On the basis of the computational analysis, the predicted epitope can be the best accessible solution to cure infections of Marburg virus

Keywords:

Epitope, HLA, MHC, docking, allergenicity, antigenic

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Published

05-10-2016
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How to Cite

Anum Munir, Shumaila Azam, Maria Manzoor, Azhar Mehmood, G. Mujtaba Shah, and Sahar Fazal. “In-Silico Epitope Based Vaccine an Excellent Solution Against Marburg Virus”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 3, no. 4, Oct. 2016, pp. 61-66, https://jipbs.com/index.php/journal/article/view/187.

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Section

Research Article