Synthesis, and in vitro antioxidant activity of novel 1, 3, 4- oxadiazole-2-thione
DOI:
https://doi.org/10.56511/JIPBS.2016.v3.i03.pp114-122Abstract
As a continuation of our efforts to discover and develop 1,3,4-oxadiazole-2-thione,a new series of 5-[4-4′-nitrophenyl)-1,3-thiazole-2yl]-1,3,4-oxadiazole-2-thione (E) were synthesized and derivatized in to mannich bases 5-[4-4′-nitro thiazole-2yl]-3-substituted-1,3,4-oxadiazole-2-thione [Ea-e]. Physical characterization of compounds which were established by performing melting point, Rf value, percentage yield and solubility. The derivative structures were identified using UV, FT-IR, 1HNMR and MASS spectral analysis. The derivatives were then screened for antioxidant activity by DPPH, Nitric oxide and Hydrogen peroxide scavenging assays. When compared with other derivatives, compound 5c was found to have maximum in vitro antioxidant activity in all the three methods. This may be due to the presence of electron donating diethyl group present in compound ‘Ec’. The electron donating nitro group may also have an influence in the antioxidant activity which is present in all derivatives.
Keywords:
1,3,4-oxadiazole, Spectroscopy, Mannich bases, DPPH and H2O2 assayDownloads
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