Development and validation of RP-HPLC method for simultaneous estimation of Naproxen and Esomeprazole in pharmaceutical dosage form

Authors

  • Haritha Gali Department of Pharmaceutical Analysis, PNR College of Pharmacy, Shamshabad, RR Dt, Telangana, India
  • Vishwanadham Yerragunta Department of Pharmaceutical Chemistry, Vishnu Institute of Pharmaceutical Education & Research, (VIPER), Narsapur, Medak Dt, Telangana, India

Abstract

The objective of the study was to develop a simple, accurate, precise RP-HPLC method for the determination of Esomeprazole and Naproxen using mobile phase (A mixture of Acetonitrile and Methanol in the ratio of 60:40 was considered to be the optimal composition of solvent) as the solvent. The proposed method was involves the measurement of retention time at selected analytical wavelength 260.0 nm was selected as the analytical wavelength. The retention time of Esomeprazole and Naproxen was found to be 3.425 and 4.352. The linearity of the proposed method was in the range of r = 0.9999 for Esomeprazole and r = 0.9999 for Naproxen. The method was statistically validated for its linearity, accuracy and precision of the formulation.

Keywords:

Esomeprazole, Naproxen, RP-HPLC method

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Published

05-07-2016
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How to Cite

Haritha Gali, and Vishwanadham Yerragunta. “Development and Validation of RP-HPLC Method for Simultaneous Estimation of Naproxen and Esomeprazole in Pharmaceutical Dosage Form”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 3, no. 3, July 2016, pp. 39-42, https://jipbs.com/index.php/journal/article/view/160.

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Research Article