Assessment of prescribing Pattern of proton Pump inhibitor and histamine 2 receptor antagonist

Abstract

Proton Pump Inhibitors (PPIs) remain the leading evidence based therapy for upper Gastro intestinal disorders, including gastro-esophageal reflux disease, dyspepsia, peptic ulcer disease, NSAID-induced ulcer, eradication of Helicobacter pylori, and hyper secretory disorders. H2 receptor antagonists like ranitidine is the first choice H2 receptor antagonist in most patient. Our study aimed about the assessment of the prescribing pattern of PPIs and H2 receptor blockers. Our other objectives were to assess therapeutic appropriateness with standard guideline, ADR &Drug Interactions related to PPI &H2 receptor antagonist.  Our study was a prospective observational study, included 209 patients, was conducted in a tertiary care Bangalore Baptist Hospital, Bangalore, INDIA for a period of six months. The   results of this study observed that males were more using PPIs than females. Therapeutic appropriateness was mostly correct among both PPIs and H2 receptor blockers. We can conclude that continuous medical education with focus on rational drug use and evidence based medicine should form part of the program of the hospital. They should be involved in collection and presentation of prescribing data as part of clinical audit and also education of patients/caretakers. Also hospitals should consider developing controlled policies like formulary restriction, stop orders for specific indications, and automatic switch-order to oral PPI if patient is receiving oral feeding. This study could provide direction for much needed randomized controlled trials evaluating the use of PPIs in the first year of life, including specific recommended dosing, duration of therapy, and effectiveness of treatment.