Comparison of lidocaine and labetalol on the hemodynamic response patients with endotracheal intubation

Abstract

Background: Comparison of lidocaine and Labetalol on the hemodynamic response patients with endotracheal intubation. Introduction: Poor physical condition, emergency intubation and use of drugs to induce anesthesia, cause complications such as hemodynamic instability. This study aims to investigate comparison of lidocaine and Labetalol on hemodynamic response in patients with endotracheal intubation. Materials and Methods: The clinical trial, randomized, single-blind study was performed with 192 patients with indication of elective non-cardiac surgery and endotracheal intubation. Patients were randomized into 3 equal groups; control group: received only anesthesia drugs; Group 1: 90 seconds before intubation received 1.5 mg/kg lidocaine, too; group 2:5 minutes before intubation received 0.4 mg/kg labetalol, too. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and mean arterial pressure (MAP) in all 3 groups at the time of intubation, 2 and 5 minutes after that were recorded. Data were analyzed by SPSS 18 software. Results: During 3-review process of the patients, SBP (lidocaine: p=0.001, labetalol: p=0.000), DBP (lidocaine: p=0.000, labetalol: p =0.01) and MAP (lidocaine: p=0.012, labetalol: p=0.05) in both lidocaine and labetalol groups, decreased significantly. HR decreased significantly only in the labetalol group (p=0.000). in control group, 2 min after intubation, all variables  significantly increased and reached to baseline 5 minutes after intubation. Conclusion: Based on our results, lidocaine and labetalol can be good protection against hemodynamic changes. However, due to conflicting results among studies (especially in field of labetalol) further studies in the future are recommended.