Impact of rotatory vestibular stimulation and Myristica fragrans on spatial learning and memory in wistar albino rats

Abstract

The altered dendritic length and de novo formation of new dendritic branches in cholinoceptive cells are responsible for learning and long term memory storage, a process enabled by the central cholinergic pathways. Living in an enriched environment and also physical activities may stimulate hippocampal neurogenesis in adult mice. Acetyl cholinesterase an enzyme that inactivates the neurotransmitter acetylcholine and the present study was undertaken to find out the enhancement of cognition in rats with Rotatory Vestibular Stimulation (RVS), and treatment with Myristica fragrans via estimating the dendritic arborization and acetylcholinesterase activity. A total of 72 adult male Wistar albino rats were randomly assigned into four groups. For Group A neither Vestibular Stimulation, nor Myristica fragranswas administered, Group B, Rotatory Vestibular Stimulation was given for 5 minutes in a Rotatory vestibular apparatus at a rate of 50 revolutions per minute in clock wise direction for 30 days, Group C treated with 2mg/kg of Myristica fragransfor 30days, and Group D, treated with 2mg/kg of Myristica fragrans followed by 5 minute of Rotatory Vestibular Stimulation for 30days in a rotatory vestibular apparatus at a rate of 50 rpm in clock wise direction for 30days. It has been concluded thatMyristica fragrans in combination of Rotatory Vestibular Stimulation provides significant improvement in cognition than vestibular stimulation and Myristica fragrans alone. From the analysis it is clear that learning and memory has improved via altering the dendritic arborization and level of AChE Hence we recommend further detailed study on combination of rotatory vestibular stimulation and Myristica fragransto explore the exactmechanism of actionunderlying in this behavioral change and the therapeutic validity for treatment of cognitive disorders.