Assessment of neurocognitive disorders in HIV infected patients receiving combination of anti-retroviral therapy at a tertiary care hospital - An observational study

Authors

  • Shwetha S Intern, Doctor of Pharmacy (Pharm D intern), Karnataka College of Pharmacy
  • Rebecca Elizabeth Chacko Intern, Doctor of Pharmacy (Pharm D intern), Karnataka College of Pharmacy
  • Dr. Blessy K George Pharm D, Assistant Professor at Karnataka College of Pharmacy.
  • Dr. Balakeshwa Ramaiah Head of Department of Pharmacy Practice, Karnataka College of Pharmacy
  • Dr. Shirley James Specialist in General Medicine and HIV medicine, Bangalore Baptist Hospital

DOI:

https://doi.org/10.56511/JIPBS.2023.10201

Abstract

cART Therapy (combination antiretroviral therapy) has improved the live expectancy of people living with HIV (PLHIV). But HIV associated neurocognitive disorders (HAND) are still prevalent. One of the factors associated could be the cART therapy itself. The study aims to calculate the prevalence of HAND and associated risk factors in PLHIV who are on Cart therapy and to compare the efficiency of MMSE and IHDS scales in the assessment of HAND. A case-control study involving 54 PLHIV on cART therapy and 27 HIV negative controls were screened for their neurocognition by two neuropsychological tests such as MMSE and IHDS, followed by staging into Asymptomatic Neurological Impairment (ANI), Mild Neurocognitive Impairment (MND), HIV Associated Dementia (HAD) in PLHIV. Statistical analysis was done using suitable software. The overall prevalence of HAND in our study was found to be 70.37%. Prevalence estimates for specific HAND diagnoses were 57.89% ANI, 28.9% MND, and 13.1 % HAD. IHDS demonstrated good screening ability for HAND with an optimal cut-off score of 10, high sensitivity of 70% and minimal specificity. Age, male gender, low literacy, presence of comorbidities, severity of the disease, cART regimen with low CPE (CNS penetration effectiveness) score were strongly correlated. Study findings suggest that IHDS serves as a better screening tool for HAND with greater sensitivity and can facilitate further cognitive evaluation. The overall prevalence was found to be equivalent to that of the recently reported studies.

Keywords:

HIV associated neurocognitive disorders, combination antiretroviral therapy, neuropsychological tests, ; Mini-Mental State Examination, International HIV Dementia Scale

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Published

05-04-2023
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How to Cite

Shwetha S, Rebecca Elizabeth Chacko, Dr. Blessy K George, Dr. Balakeshwa Ramaiah, and Dr. Shirley James. “Assessment of Neurocognitive Disorders in HIV Infected Patients Receiving Combination of Anti-Retroviral Therapy at a Tertiary Care Hospital - An Observational Study”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 10, no. 2, Apr. 2023, pp. 01-07, doi:10.56511/JIPBS.2023.10201.

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Section

Research Article