Antioxidant activity and α-glucosidase inhibition effect of water extract of Saurauia vulcani Korth leaves

Authors

  • Tri Nova Lovena Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia
  • Urip Harahap Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia
  • Panal Sitorus Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia
  • Denny Satria Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia

Abstract

Objective: Saurauia vulcani, Korth leaves contain several compounds such as polyphenols which have activity as the antioxidant. This plant is used traditionally in the treatment of diabetes mellitus and wound healing. Methods: Saurauia vulcani, Korth leaves powder was extracted by infundation method with water as solvent.This aim of this study was to determined the total content of phenol and flavonoid, antioxidant activity in DPPH method and activity of the α-glucosidase enzyme inhibition of water extract of Saurauia vulcani Korth leaf. Result: The results were showed that water extract has a total phenol content of 96.75± 0.02 mg/g GAE, a total flavonoid content of 39.50 ± 0.02 mg/g QE, antioxidant activity with DPPH method has an IC50 value 22.918 ± 1.32 µg/mL and the highest activity inhibition with IC50 value 75.56 ± 1.07μg/mL. Conclusion: Based on the results obtained that the water extract leaves of Saurauia vulcanihas a total phenol content, a total flavonoid content, antioxidant activity with DPPH method and inhibition of enzyme activity α-glucosidase giving synergistic effect

Keywords:

Antioxidant, vulcani korth, enzymeα-glucosidase, total phenol, total flavonoid

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Published

05-07-2018
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How to Cite

Lovena, T. N., Urip Harahap, Panal Sitorus, and Denny Satria. “Antioxidant Activity and α-Glucosidase Inhibition Effect of Water Extract of Saurauia Vulcani Korth Leaves”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 5, no. 3, July 2018, pp. 47-51, https://jipbs.com/index.php/journal/article/view/330.

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Research Article