In-vitro cytotoxic studies of Cordia monoica (Roxb.) leaves on HeLa E 139 cell lines

Abstract

Aim: The present study was carried out to determine the cytotoxicity of Cordia monoica (Roxb.) leaves on cancer cell lines.  Materials and methods: Cordia monoica (Roxb.) belongs to Boraginaceae family and is commonly known as sand paper. The flowers are cream in color and turn brown on drying. The leaves of the plant have a texture of sandpaper. The Leaves of          C. monoica was extracted with ethanol and subjected for in-vitro anti-tumor studies. The in-vitro Cytotoxicity screening was carried out with HeLa E 139 cell line using MTT assay. Result: The study indicated that the extract is toxic to the cell at higher concentration and was dose dependent. The plant extract has cytotoxic effects on HeLa E 139 cell line as concentration increases. Conclusion: Hence, the present study supports C. monoica (Roxb.) can be a potent anti-cancer herb if it is exploited