Stability studies on Lincomycin HCl using validated developed second derivative spectrophotometric method
Objectives: A previously developed second derivative spectrophotometric method was applied for the stability studies of lincomycin under stress conditions in accordance to VICH guidelines. Method: The studied factors were pH, alkali, acid, temperature and light. Results: A constructed pH profile revealed the degradation rate dependence on [OH-]. Arrhenius plot obtained at pH 10 was linear between 70°C and 100°C. The estimated activation energy of the hydrolysis was found to be 17.4 kcal mol-1. Photochemical studies were also conducted. Conclusion: Lincomycin was found unstable in alkali and high temperature.
Keywords:Lincomycin, Stability, Second derivative, Stress conditions, Hydrolysis
How to Cite
Copyright (c) 2017 Shaza W. Shantier, Mohammed M. Elimam, Magdi A. Mohamed, Elrasheed A. Gadkariem
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.