Stability studies on Lincomycin HCl using validated developed second derivative spectrophotometric method

Authors

  • Shaza W. Shantier Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, Sudan
  • Mohammed M. Elimam Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, Sudan
  • Magdi A. Mohamed Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, Sudan
  • Elrasheed A. Gadkariem Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, Sudan

Abstract

Objectives: A previously developed second derivative spectrophotometric method was applied for the stability studies of lincomycin under stress conditions in accordance to VICH guidelines. Method: The studied factors were pH, alkali, acid, temperature and light. Results: A constructed pH profile revealed the degradation rate dependence on [OH-]. Arrhenius plot obtained at pH 10 was linear between 70°C and 100°C. The estimated activation energy of the hydrolysis was found to be 17.4 kcal mol-1. Photochemical studies were also conducted. Conclusion: Lincomycin was found unstable in alkali and high temperature.

Keywords:

Lincomycin, Stability, Second derivative, Stress conditions, Hydrolysis

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Published

05-10-2017
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How to Cite

Shaza W. Shantier, Mohammed M. Elimam, Magdi A. Mohamed, and Elrasheed A. Gadkariem. “Stability Studies on Lincomycin HCl Using Validated Developed Second Derivative Spectrophotometric Method”. Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 4, no. 4, Oct. 2017, pp. 141-4, https://jipbs.com/index.php/journal/article/view/270.

Issue

Volume 4, Issue 4, 2017 (Oct-Dec)

Section

Research Article

Copyright (c) 2017 Shaza W. Shantier, Mohammed M. Elimam, Magdi A. Mohamed, Elrasheed A. Gadkariem

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