Stability studies on Lincomycin HCl using validated developed second derivative spectrophotometric method
Abstract
Objectives: A previously developed second derivative spectrophotometric method was applied for the stability studies of lincomycin under stress conditions in accordance to VICH guidelines. Method: The studied factors were pH, alkali, acid, temperature and light. Results: A constructed pH profile revealed the degradation rate dependence on [OH-]. Arrhenius plot obtained at pH 10 was linear between 70°C and 100°C. The estimated activation energy of the hydrolysis was found to be 17.4 kcal mol-1. Photochemical studies were also conducted. Conclusion: Lincomycin was found unstable in alkali and high temperature.
Keywords:
Lincomycin, Stability, Second derivative, Stress conditions, HydrolysisDownloads
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Copyright (c) 2017 Shaza W. Shantier, Mohammed M. Elimam, Magdi A. Mohamed, Elrasheed A. Gadkariem

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