Formulation of Chlorpheniramine maleate in span 60/ tween20 based organogels for transdermal delivery
DOI:
https://doi.org/10.56511/JIPBS.2017.v4.i01.pp49-57Abstract
Objectives: Transdermal drug delivery is an attractive alternative to the oral route of drug administration due to avoidance of the first pass effect, reduced adverse reactions and better patient compliance. The aim of the study was to formulate chlorpheniramine maleate in anorganogel base in order to overcome the problems related with oral route. Materials and methods: Different organogels were prepared using a mixture of span60 and tween 20 in sunflower oil at 60˚C. The formulated organogels were evaluated for physical appearance, emulsion type, drug content, pH, viscosity, gel-sol transition temperature, spreadability and in vitro drug release through cellophane membrane. The permeation of the optimum formulation through rat skin was compared with organogels containing different concentrations of menthol. Finally, the efficiency of organogel formulation with the highest skin permeation was studied in vivo and compared with oral Chlorpheniramine maleate. Results: All the prepared organogels exhibited acceptable physical properties. Surfactant mixture / water ratio and viscosity had significant effects (P < 0.05) on % drug release. Incorporation of 5% menthol significantly improved chlorpheniramine maleate permeation through rat skin. Skin irritancy testing showed no allergic manifestation. Promising edema inhibition within one hour was observed for 2% and 5% Chlorpheniramine maleate organogel rather than oral route. Conclusion: Transdermal application of chlorpheniramine maleate in organogels may be a promising alternative to the oral route.
Keywords:
organogel, chlorpheniramine maleate, tween 20, span 60, sunflower oilDownloads
References
Shingade GM, Quazi A, Sabale PM, Grampurohit ND, Gadhave MV, Jadhav SL, Gaikwad DD: Review on: recent trend on transdermal drug delivery system. Journal of Drug Delivery and Therapeutics 2012; 2(1): 66-75
Alsaab H, Prabha SB , Bahl D, Chowdhury P, Alexander K, Boddu SHS: Orgaogels in drug delivery: A special emphasis on pluronic lecithin organogels. Journal of Pharmaceutics and Pharmaceutical Sciences2016; 19(2): 252 – 273.
Esch JV, Schoonbeek F, De Loos M, Veen EM, Kellogg RM, Feringa VL: Low molecular weight gelators for organic solvents. Supramolecular Science 1999; 6: 233 – 259.
Vintiloiu A, Leroux JC: Organogels and their use in drug delivery-A review. Journal of Controlled Release 2008; 125(3): 179-192.
Balaguru S, Ramya Devi D, Vedha Hari B N: Organogel: An ideal drug delivery carrier for non steroidal anti-Inflammatory drugs through topical route. International Journal of Pharmaceutical Quality Assurance 2015; 6(2): Article 2.
Moniruzzaman M, Sahin A, Winey KI: Improved mechanical strength and electrical conductivity of organogels containing carbon nanotubes. Carbon 2009; 47(3): 645-650.
Bastiat G, François P, Motulsky A, Alexandra F, Yvan D, Rémi Q, Fuhrmann G, Leroux J: Tyrosine-based rivastigmine-loaded organogels in the treatment of alzheimer’s disease. Biomaterials 2010; 31(23): 6031 - 6038.
Nasseri AA, Aboofazeli R, Zia H, Needham TE: Lecithin-stabilized microemulsions-based organogels for topical application of ketorolac tromethamineIn vitro release study. Iranian Journal of Pharmaceutical Research 2005; 5: 117-124.
Wright A, Marangoni A: Formation, structure and rheological properties of ricinelaidic acid-vegetable oil organogels. Journal of the American Oil Chemists' Society 2006; 83(6): 497-503.
Kreilgaard M, Pedersen EJ, Jaroszewski JWJ: NMR characterization and transdermal drug delivery potential of microemulsion systems. Journal of Controlled Release 2000; 69(3): 421-433.
Ceschel GC, Maffei, P, Gentile M: Design and evaluation of a new transdermal formulation containing chlorpheniramine maleate. Drug Development and Industrial Pharmacy 1999; 25(9): 1035-1039.
Hyma P, Jahan N, Raheemunissa, Sreelekha G, Babu K: Formulation and evaluation of novel topical emulgel of chlorpheniramine maleate. International Journal of Current Trends in Pharmaceutical Research 2014; 2: 459-467.
Joshi H, Nand I, Bari M: Study of isopropyl myristatemicroemulsion systems containing cyclodextrins to improve the solubility of two model hydrophobic drugs. AAPS Pharmaceutical Science and Technology 2003; 4(1): 1-9.
Flynn LG. Cutaneous and transdermal delivery: Processes and systems of delivery, In: Modern Pharmaceutics, 3rded, Marcel Dekker Inc.: New York, USA. 1996.
Raut S, Suruse PB, Shivhare UD, Bhusari KB: Development and evaluation of non-ionic surfactant based organogels for transdermal delivery of zidovudine. Pharmacie Globale (IJCP) 2010; 3(7): 1-10.
AbdulbariMM, Ihsan M: Simultaneous determination and validation of chlorpheniramine maleate, acetaminophen, phenylpropanolamine hydrochloride and caffeine in tablet dosage form by using reverse phase high performance liquid chromatography (RP-HPLC). International Journal of Pharmaceutics and Pharmaceutical Sciences 2013; 5(3): 666670.
Tas C, O¨zkan Y, Savaser A, Baykara T: In vitro release studies of chlorpheniramine maleate from gels prepared by different cellulose derivatives. Farmaco 2003; 58(8): 605-611.
Barakat NS: Evaluation of glycofurol-based gel as a new vehicle for topical application of naproxen. AAPS Pharmaceutical Sciences and Technology 2010; 11(3): 1138 – 1146.
Shaikh IM, Jadhav SL, Jadhav KR, Kadam VJ, Pisal SS: Aceclofenac organogels: In vitro and in vivo characterization. Current Drug Delivery 2009; 6(1): 1-7.
Thakur NK, Bharti P, Mahant S, Rao R: Formulation and characterization of benzoyl peroxide jellified emulsions. Sciencia Pharmaceutica 2012; 80(4):1045 – 1060.
Aly UF: Preparation and evaluation of novel topical gel preparations for wound healing in diabetics. International Journal of Pharmaceutics and Pharmaceutical Sciences 2012; 4:1.
Kulkarni SK, Jain NK. Pharmacological and pharmacokinetic studies on marketed gel formulations of nimesulide. Indian Drugs 2001; 38: 63-66.
Tamaddonfard E, Hamzeh-Gooshchi N: Effect of crocin on the morphineinduced anti-nociception in the formalin test in rats. Phytotherapy Research 2010; 24(3): 410-413.
Bilici D, Akpinar E, Gursan N, Ozbakis-Dengiz G, Bilici S, Altas S: Protective effect of T-type calcium channel blocker in histamine-induced paw inflammation in rats. Pharmacol Research 2001; 44(6): 527-531.
Farshid AA, Tamaddonfard E, Morvaridi A: Effects of histidine and dexamethasone on the local inflammation induced by histamine in rats. Vetrinary Research Forum 2011; 2: 31-36.
TimeaPenzes: Optimization and evaluation of topical used pharmaceutical organogels. Ph-D Thesis. Department of Pharmaceutical Technology, University of Szeged 2005; 2
Dharashivkar S, Sahasrabuddhe S, Saoji A: Silver sulfadiazine niosomes: A novel sustained release once a day formulation for burn treatment. International Journal of Pharmaceutics and Pharmaceutical Sciences 2014; 6(1): 611-616.
Murdan S, Gregoriadis G, Florence AT: Nonionic surfactant based organogels incorporating niosomes. STP Pharmaceutical Sciences 1996; 6:44-48.
Rushikesh P, Abraham S, Bharath S, Madhavan V: Sorbitan monostearate based organogels for topical delivery of clotrimazole. International Journal of Pharmaceutical and Chemical Sciences 2013; 2(3):1246-1252.
Singh VK, Pramanik K, Ray SS, Pal1 K. : Development and characterization of sorbitanmonostearate and sesame oil - based organogels for topical delivery of antimicrobials. AAPS Pharmaceutical Sciences and Technology 2015; 16 ( 2 ) : 293 - 305 .
Wan Rusmawati WM, Dzulkefly K, Lim WH: Emulsion properties of mixed tween20-span20 in non-aqueous system. Pertanika Journal of Science and Technology 2002; 10(2): 153 – 160.
Jibry N, Heenan RK, Murdan S: Amphiphilogels for drug delivery: Formulation and characterization. Pharmaceutical Research 2004; 21(10): 1852-1861.
Kamada M, Shimizu S, Aramaki K: Manipulation of viscosity behavior of wormlike micellar gel by changing the molecular structure of added perfumes. Colloids and Surfaces. A Physicochemical and Engineering Aspects 2004; 458:110-116.
Kumar TS: Preparation and characterization of novel span 80: tween-80 based organogels for food and pharmaceutical industries. Master of Technology in Biomedical Engineering, National Institute of Technology, Rourkela, Odisha, 2011; 25.
Pawar S, Jahagirdar A, Kolkar D, Patil M, Udavant P, Kshirsagar S: Investigation of potential of organogel carrying etodolac for antiinflammatory activity. Journal of Pharmaceutical Biology 2015; 2: 284297.
Sinha VR, Kaur MP: Permeation enhancers for transdermal drug delivery. Drug Delivery and Industrial Pharmacy 2000; 26(11):1131 – 1140.
Ozbakis-Dengiz G, Halici Z, Akpinar E: Role of polymorphonuclear leukocyte infiltration in the mechanism of anti-inflammatory effect of amiodarone. Pharmacology Report Journal 2007; 59: 538-544.
Arya S, Kumar VL: Anti-inflammatory efficacy of extracts of latex of Calotropisproceraagainst different mediators of inflammation. Mediators of Inflammation 2005; 4: 228-232.
Inoue H, Nagata N, Koshihara Y: Involvement of tachykinin receptors in oedema formation and plasma extravasation induced by substance P, neurokinin A, and neurokinin B in mouse ear. Inflammation Research Journal 1996; 45:316-323.
Sahoo CK, Satyanarayana K, Bomma NG, Modugu KR, Nayak PK, Sarangi DK: Formulation and evaluation of bifonazoleorganogel for the application of topical drug delivery system. International Journal of Medicine and Pharmaceutical Research (IJMPR) 2013; 1(1):170-178.
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